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SORL1 wt Allele

Known as: Sortilin-Related Receptor, L(DLR Class) A Repeats-Containing Gene, gp250, LR11 
Human SORL1 wild-type allele is located within 11q23.2-q24.2 and is approximately 182 kb in length. This allele, which encodes sortilin-related… 
National Institutes of Health

Related topics

Related topics

7 relations
Ligand BindingProtein Degradation, MetabolicReceptor Mediated EndocytosisReceptor Signaling

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
SORL1 rs1699102 polymorphism modulates age‐related cognitive decline and gray matter volume reduction in non‐demented individuals
SORL1 rs1699102 is associated with the risk of late‐onset Alzheimer's disease. However, the effects of this single nucleotide… 
2017
2017
SORLA attenuates EphA4 signaling and amyloid β–induced neurodegeneration
Sortilin-related receptor with LDLR class A repeats (SORLA, SORL1, or LR11) is a genetic risk factor associated with Alzheimer’s… 
2016
2016
Polarized trafficking of the sorting receptor SorLA in neurons and MDCK cells
The sorting receptor SorLA is highly expressed in neurons and is also found in other polarized cells. The receptor has been… 
2013
2013
SORLA-Mediated Trafficking of TrkB Enhances the Response of Neurons to BDNF
Stimulation of neurons with brain-derived neurotrophic factor (BDNF) results in robust induction of SORLA, an intracellular… 
2011
2011
APP involvement in retinogenesis of mice
Very few studies have examined expression and function of amyloid precursor protein (APP) in the retina. We showed that APP mRNA… 
Highly Cited
2010
Highly Cited
2010
SORLA/SORL1 Functionally Interacts with SPAK To Control Renal Activation of Na+-K+-Cl− Cotransporter 2
ABSTRACT Proper control of NaCl excretion in the kidney is central to bodily functions, yet many mechanisms that regulate… 
Highly Cited
2009
Highly Cited
2009
Brain-Derived Neurotrophic Factor Reduces Amyloidogenic Processing through Control of SORLA Gene Expression
Sorting protein-related receptor with A-type repeats (SORLA) is a major risk factor in cellular processes leading to Alzheimer's… 
Highly Cited
2006
Highly Cited
2006
Interaction of the Cytosolic Domains of sorLA/LR11 with the Amyloid Precursor Protein (APP) and β-Secretase β-Site APP-Cleaving Enzyme
sorLA is a recently identified neuronal receptor for amyloid precursor protein (APP) that is known to interact with APP and… 
Highly Cited
2006
Highly Cited
2006
Tumour necrosis factor alpha-converting enzyme mediates ectodomain shedding of Vps10p-domain receptor family members.
Several transmembrane molecules are cleaved at juxtamembrane extracellular sites leading to shedding of ectodomains. We analysed… 
Highly Cited
2003
Highly Cited
2003
High level of cannabinoid receptor 1, absence of regulator of G protein signalling 13 and differential expression of Cyclin D1 in mantle cell lymphoma
Mantle cell lymphoma (MCL) is a moderately aggressive B-cell lymphoma that responds poorly to currently used therapeutic… 
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