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SOD1 gene

Known as: Superoxide Dismutase 1, Soluble (Amyotrophic Lateral Sclerosis 1 (Adult)) Gene, SUPEROXIDE DISMUTASE, SOLUBLE, SUPEROXIDE DISMUTASE, COPPER-ZINC 
This gene plays a role in the detoxification of superoxide radicals in the cytosol.
National Institutes of Health

Related topics

Related topics

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AMYOTROPHIC LATERAL SCLEROSIS 1Amyotrophic Lateral SclerosisCu-Zn Superoxide DismutaseMetabolic Detoxication, Drug

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SOD1 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Computational investigation of the human SOD1 mutant, Cys146Arg, that directs familial amyotrophic lateral sclerosis.
The genetic substitution mutation of Cys146Arg in the SOD1 protein is predominantly found in the Japanese population suffering… 
2016
2016
Mice Overexpressing Both Non-Mutated Human SOD1 and Mutated SOD1G93A Genes: A Competent Experimental Model for Studying Iron Metabolism in Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by degeneration and loss of motor… 
2015
2015
Direct and indirect mechanisms for wild-type SOD1 to enhance the toxicity of mutant SOD1 in bigenic transgenic mice.
Co-expression of wild-type human superoxide dismutase 1 (WT-hSOD1) with ALS mutant hSOD1 accelerates disease onset relative to… 
2014
2014
Association of CAT C-262T and SOD1 A251G single nucleotide polymorphisms susceptible to gastric cancer
Oxidative stress is known to be one of the major factors involved in the development and progression of cancer. Oxidative stress… 
Highly Cited
2013
Highly Cited
2013
Superoxide dismutase 1 overexpression in mice abolishes maternal diabetes-induced endoplasmic reticulum stress in diabetic embryopathy.
Highly Cited
2010
Highly Cited
2010
Separate and combined effects of Sod1 and Cdh23 mutations on age-related hearing loss and cochlear pathology in C57BL/6J mice
2008
2008
Lysyl-tRNA Synthetase Is a Target for Mutant SOD1 Toxicity in Mitochondria*
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease affecting the motor neurons. The majority of… 
2008
2008
Identification of functionally important amino acids in a novel indigo-producing oxygenase from Rhodococcus sp. strain T104
A novel indigo-producing oxygenase gene, designated ipoA (1,197 bp) was characterized from Rhodococcus sp. strain T104. Three… 
2006
2006
Novel Mutations that Enhance or Repress the Aggregation Potential of SOD1
Mutations in SOD1 cause FALS by a gain of function likely related to protein misfolding and aggregation. SOD1 mutations encompass… 
Highly Cited
2001
Highly Cited
2001
Stabilization of mutant Cu/Zn superoxide dismutase (SOD1) protein by coexpressed wild SOD1 protein accelerates the disease progression in familial amyotrophic lateral sclerosis mice
Transgenic mice carrying familial amyotrophic lateral sclerosis (FALS)‐linked mutant Cu/Zn superoxide dismutase (SOD1) genes such… 
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