SOCS3 gene

Known as: Suppressor of Cytokine Signaling 3 Gene, CIS3, SOCS3 
This gene is involved in the regulation of cytokine-mediated signaling.
National Institutes of Health

Papers overview

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Review
2014
Review
2014
IL-6 a multi-functional cytokine with important effects in both inflammation and haematopoiesis. SOCS3 is the primary inhibitor… (More)
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2013
2013
The significance of loss of SOCS3, a negative regulator of signalling pathways including those of STAT3 and NF-κB, was examined… (More)
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Highly Cited
2012
Highly Cited
2012
Janus kinases (JAKs) are key effectors in controlling immune responses and maintaining hematopoiesis. SOCS3 (suppressor of… (More)
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2008
2008
BACKGROUND The JAK2 V617F mutation can be found in patients with polycythemia vera, essential thrombocythemia and idiopathic… (More)
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Highly Cited
2006
Highly Cited
2006
Suppressor of cytokine signaling (Socs) 3 is a cytokine-inducible inhibitor with critical but selective cell-specific effects. We… (More)
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Highly Cited
2005
Highly Cited
2005
Cytokine responses can be regulated by a family of proteins termed suppressors of cytokine signaling (SOCS) which can inhibit the… (More)
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Highly Cited
2003
Highly Cited
2003
The suppressors of cytokine signaling (SOCS) are negative feedback inhibitors of cytokine and growth factor-induced signal… (More)
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Highly Cited
2001
Highly Cited
2001
Immune and inflammatory systems are controlled by multiple cytokines, including ILs and INFs. These cytokines exert their… (More)
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Highly Cited
1999
Highly Cited
1999
SOCS3 (CIS3/JAB2) is an SH2-containing protein that binds to the activation loop of Janus kinases, inhibiting kinase activity… (More)
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Highly Cited
1999
Highly Cited
1999
BACKGROUND The Janus family of protein tyrosine kinases (JAKs) regulate cellular processes involved in cell growth… (More)
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