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SN30000

National Institutes of Health

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Broader (1)

CEN-209

Papers overview

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2018
2018
Abstract 2440: Potentiation of the action of chemotherapeutic drugs by the hypoxia-activated prodrug SN30000 in multicellular tumor spheroids
Introduction: Chemotherapy is often limited by resistant subpopulations of tumor cells. Tumor hypoxia contributes to resistance… 
2017
2017
Abstract 4523: Agent-based models for prediction of tumor spheroid response to radiation and the hypoxia-activated prodrug SN30000
2014
2014
Small Molecule Therapeutics Dual Targeting of Hypoxia and Homologous Recombination Repair Dysfunction in Triple-Negative Breast Cancer
Triple-negative breast cancer (TNBC) is an aggressive malignancy with poor clinical outcome and few validated drug targets. Two… 
2013
2013
Zinc Finger Nuclease Knock-out of NADPH:Cytochrome P450 Oxidoreductase (POR) in Human Tumor Cell Lines Demonstrates That Hypoxia-activated Prodrugs Differ in POR Dependence*
Background: NADPH:cytochrome P450 oxidoreductase (POR) catalyzes one-electron reduction of hypoxia-activated prodrugs (HAP… 
2012
2012
Introducing Drug Transport Early in the Design of Hypoxia Selective Anticancer Agents Using a Mathematical Modelling Approach
Hypoxia is more severe in tumors than normal tissues, and contributes to tumor progression and therapeutic resistance. It is… 
2011
2011
EF5 as a predictive biomarker for activation of the new hypoxia-targeting prodrug SN30000.
e13597 Background: SN30000 (CEN-209), a benzotriazine-N-oxide, is a second generation analogue of tirapazamine (TPZ) and is… 
2011
2011
Abstract 5306: 18F-EF5 microPET imaging of treatment response from a novel, hypoxia-selective cytotoxin SN30000 in a human lung cancer xenograft model
Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL Introduction: SN30000 (CEN-209) is a structural… 
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