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SN30000

 
National Institutes of Health

Papers overview

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2018
2018
Multicellular tumour spheroids capture many characteristics of human tumour microenvironments, including hypoxia, and represent… Expand
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2017
2017
3-(3-Morpholinopropyl)-7,8-dihydro-6H-indeno[5,6-e][1,2,4]triazine 1,4-dioxide (SN30- 000), an analog of the well-studied… Expand
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2015
2015
Hypoxia is a prevalent feature of many tumors contributing to disease progression and treatment resistance, and therefore… Expand
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2014
2014
SN30000 is a second-generation benzotriazine-N-oxide hypoxia-activated prodrug scheduled for clinical trial. Previously we showed… Expand
2014
2014
The radical species underlying the activity of the bioreductive anticancer prodrug, SN30000, have been identified by electron… Expand
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2014
2014
Triple-negative breast cancer (TNBC) is an aggressive malignancy with poor clinical outcome and few validated drug targets. Two… Expand
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2013
2013
Hypoxia is a significant therapeutic problem for solid tumors because hypoxic cells are treatment-resistant and more aggressive… Expand
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Review
2013
Review
2013
Hypoxia contributes to resistance of tumors to some cytotoxic drugs and to radiotherapy, but can in principle be exploited with… Expand
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Highly Cited
2011
Highly Cited
2011
Purpose: Benzotriazine-N-oxide bioreductive prodrugs such as tirapazamine and its improved analogue CEN-209 (SN30000) have… Expand
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Highly Cited
2010
Highly Cited
2010
Purpose: Tirapazamine (TPZ) has attractive features for targeting hypoxic cells in tumors but has limited clinical activity, in… Expand
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