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SN30000

National Institutes of Health

Papers overview

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2018
2018
Multicellular tumour spheroids capture many characteristics of human tumour microenvironments, including hypoxia, and represent… 
2017
2017
3-(3-Morpholinopropyl)-7,8-dihydro-6H-indeno[5,6-e][1,2,4]triazine 1,4-dioxide (SN30- 000), an analog of the well-studied… 
Highly Cited
2015
Highly Cited
2015
Hypoxia is a prevalent feature of many tumors contributing to disease progression and treatment resistance, and therefore… 
2014
2014
Triple-negative breast cancer (TNBC) is an aggressive malignancy with poor clinical outcome and few validated drug targets. Two… 
2014
2014
The radical species underlying the activity of the bioreductive anticancer prodrug, SN30000, have been identified by electron… 
2013
2013
Hypoxia is a significant therapeutic problem for solid tumors because hypoxic cells are treatment-resistant and more aggressive… 
Highly Cited
2011
Highly Cited
2011
Purpose: Benzotriazine-N-oxide bioreductive prodrugs such as tirapazamine and its improved analogue CEN-209 (SN30000) have… 
Highly Cited
2010
Highly Cited
2010
Purpose: Tirapazamine (TPZ) has attractive features for targeting hypoxic cells in tumors but has limited clinical activity, in…