SN30000
National Institutes of Health
Papers overview
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Multicellular tumour spheroids capture many characteristics of human tumour microenvironments, including hypoxia, and represent…
3-(3-Morpholinopropyl)-7,8-dihydro-6H-indeno[5,6-e][1,2,4]triazine 1,4-dioxide (SN30- 000), an analog of the well-studied…
Hypoxia is a prevalent feature of many tumors contributing to disease progression and treatment resistance, and therefore…
Triple-negative breast cancer (TNBC) is an aggressive malignancy with poor clinical outcome and few validated drug targets. Two…
The radical species underlying the activity of the bioreductive anticancer prodrug, SN30000, have been identified by electron…
Hypoxia is a significant therapeutic problem for solid tumors because hypoxic cells are treatment-resistant and more aggressive…
Purpose: Benzotriazine-N-oxide bioreductive prodrugs such as tirapazamine and its improved analogue CEN-209 (SN30000) have…
Purpose: Tirapazamine (TPZ) has attractive features for targeting hypoxic cells in tumors but has limited clinical activity, in…