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Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
TLDR
This work shows that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity, and suggests that CD133-positive tumour cells could be the source of tumour recurrence after radiation.
Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice.
TLDR
It is suggested that MCT1 inhibition has clinical antitumor potential because it was found to be expressed by an array of primary human tumors and there is therefore a symbiosis in which glycolytic and oxidative tumor cells mutually regulate their access to energy metabolites.
Basic principles of thermal dosimetry and thermal thresholds for tissue damage from hyperthermia
TLDR
This review summarizes the basic principles that govern the relationships between thermal exposure (temperature and time of exposure) and thermal damage, with an emphasis on normal tissue effects and notes the critical lack of publications examining effects of chronic thermal exposures as might be encountered in occupational hazards.
Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response
TLDR
A constant theme emerges: inhibition of HIF1 activity will have therapeutic benefit, both spatially and temporally, in the hypoxic environment of tumours.
Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma.
TLDR
The 18-month actuarial disease-free survival was 70% for patients with tumor median oxygen pressure (pO2) values of >10 mm Hg but only 35% for those with median pO2 values of <10mm Hg (P=0.01); potential mechanisms and implications for clinical trial design are discussed.
A new temperature-sensitive liposome for use with mild hyperthermia: characterization and testing in a human tumor xenograft model.
TLDR
A new lipid formulation containing doxorubicin that has been optimized for both mild hyperthermic temperatures and rapid release times is described, found to be significantly more effective than free drug or current liposome formulations at reducing tumor growth in a human squamous cell carcinoma xenograft line.
Tumor vascular permeability, accumulation, and penetration of macromolecular drug carriers.
TLDR
Increasing the molecular weight of dextran statistically significantly reduced its tumor vascular permeability and had the highest accumulation in solid tumors but were largely concentrated near the vascular surface.
Green's Function Methods for Analysis of Oxygen Delivery to Tissue by Microvascular Networks
TLDR
Numerical methods based on a Green's function approach are presented, for realistic three-dimensional network geometries derived from observations of skeletal muscle, brain, and tumor tissues, and a new version of the method is described that avoids this problem and can be applied to arbitrarily shaped tissue domains.
Randomized trial of hyperthermia and radiation for superficial tumors.
TLDR
Adjuvant hyperthermia with a thermal dose more than 10 CEM 43 degrees C T(90) confers a significant local control benefit in patients with superficial tumors receiving radiation therapy.
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