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Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
Ionizing radiation represents the most effective therapy for glioblastoma (World Health Organization grade IV glioma), one of the most lethal human malignancies, but radiotherapy remains only… Expand
Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice.
- P. Sonveaux, F. Végran, +12 authors M. Dewhirst
- Medicine, Biology
- The Journal of clinical investigation
- 1 December 2008
Tumors contain oxygenated and hypoxic regions, so the tumor cell population is heterogeneous. Hypoxic tumor cells primarily use glucose for glycolytic energy production and release lactic acid,… Expand
Basic principles of thermal dosimetry and thermal thresholds for tissue damage from hyperthermia
- M. Dewhirst, B. Viglianti, M. Lora-Michiels, M. Hanson, P. Hoopes
- International journal of hyperthermia : the…
- 1 January 2003
This paper is one of several in this Special Issue of the International Journal of Hyperthermia that discusses the current state of knowledge about the human health risks of hyperthermia. This… Expand
Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules.
Through a poorly understood mechanism, tumors respond to radiation by secreting cytokines capable of inhibiting apoptosis in endothelial cells, thereby diminishing treatment response by minimizing… Expand
Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response
Hypoxia and free radicals, such as reactive oxygen and nitrogen species, can alter the function and/or activity of the transcription factor hypoxia-inducible factor 1 (HIF1). Interplay between free… Expand
A new temperature-sensitive liposome for use with mild hyperthermia: characterization and testing in a human tumor xenograft model.
The single biggest challenge now facing drug delivery (for liposomes and indeed other carriers) is to initiate and produce release of the encapsulated drug only at the diseased site and at… Expand
Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma.
This study was performed to explore the relationship between tumor oxygenation and treatment outcome in human soft tissue sarcoma. Twenty-two patients with nonmestastatic, high-grade, soft tissue… Expand
Tumor vascular permeability, accumulation, and penetration of macromolecular drug carriers.
- M. Dreher, W. Liu, C. R. Michelich, M. Dewhirst, F. Yuan, A. Chilkoti
- Medicine, Biology
- Journal of the National Cancer Institute
- 1 March 2006
BACKGROUND Delivery of anticancer therapeutic agents to solid tumors is problematic. Macromolecular drug carriers are an attractive alternative drug delivery method because they appear to target… Expand
Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck.
- D. Brizel, G. Sibley, L. Prosnitz, R. Scher, M. Dewhirst
- International journal of radiation oncology…
- 1 May 1997
PURPOSE Tumor hypoxia adversely affects short term clinical radiation response of head and neck cancer lymph node metastases and long term disease-free survival (DFS) in cervix carcinoma. This study… Expand
Randomized trial of hyperthermia and radiation for superficial tumors.
- E. Jones, J. Oleson, +5 authors M. Dewhirst
- Journal of clinical oncology : official journal…
- 1 May 2005
PURPOSE Randomized clinical trials have demonstrated hyperthermia (HT) enhances radiation response. These trials, however, generally lacked rigorous thermal dose prescription and administration. We… Expand