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Comparison of the Hypoxia PET Tracer 18F-EF5 to Immunohistochemical Marker EF5 in 3 Different Human Tumor Xenograft Models
The availability of 18F-labeled and unlabeled 2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)-acetamide (EF5) allows for a comparative assessment of tumor hypoxia by PET andExpand
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Chemical reactivity of the 18F electrophilic reagents from the 18O(p,n) 18F gas target systems.
A comprehensive evaluation of the reactivity of 18F electrophilic fluorinating agents derived from the 18O(p,n)18F reaction conducted in target bodies made of aluminum, silver, copper, nickel, andExpand
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3-(2'-[18F]fluoroethyl)spiperone, a potent dopamine antagonist: synthesis, structural analysis and in-vivo utilization in humans.
The synthesis of 3-(2'-[18F]fluoroethyl)spiperone (1c), a radiotracer useful for imaging the brain dopamine receptor system in vivo using positron emission tomography, is described. Precursors of 1c,Expand
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In-target production of [13N]ammonia via proton irradiation of dilute aqueous ethanol and acetic acid mixtures.
A reliable, reproducible method has been developed for the in situ production of decicurie quantities of [13N]ammonia by proton irradiation of pressurized, dilute aqueous solutions of acetic acid andExpand
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Experimentally Determined Thick Target Yields for the 14N (ρ,α)11C Reaction
Thick target yields and absolute cross sections for the 1 4 N(p, a) 1 C reaction were measured at the Brookhaven tandem Van de Graaff and 60-inch cyclotron Facilities for proton energies in the rangeExpand
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Regioselective radiofluorodestannylation with [18F]F2 and [18F]CH3COOF: a high yield synthesis of 6-[18F]Fluoro-L-dopa.
A protected 6-trimethylstannyl dopa derivative 6 has been synthesized for the first time as a precursor for the preparation of 6-[18F]fluoro-L-dopa. The tin derivative 6 readily reacted withExpand
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Remote, semiautomated production of 6-[18F]fluoro-L-dopa for human studies with PET.
Regioselective radiofluorodemercuration of the 6-mercurio derivative 5 with [18F]acetylhypofluorite afforded, after acidic hydrolysis, 6-[18F]fluoro-L-3,4-dihydroxyphenylalanine (6-FD, 1) with aExpand
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N-[18F]fluoro-N-alkylsulfonamides: novel reagents for mild and regioselective radiofluorination.
N-[18F]fluoro-N-alkylsulfonamides were synthesized by the fluorination of secondary sulfonamides with [18F]F2. Radiochemical yields up to 45% (out of a maximum possible yield of 50%) for theseExpand
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Metals suitable for fluorine gas target bodies: first use of aluminum for the production of [18F]F2.
A comprehensive evaluation of different metals (aluminum, silver, copper, nickel, and gold-plated copper) was undertaken for the fabrication of target bodies with straight and conical bore shapes forExpand
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Routine Production of [18F]F2 from 11 MeV Proton-Only Cyclotron and Its Use for the Synthesis of 18F-Tracers for Heart and Brain
Although an increasing number of PET centres are using small proton-only cyclotrons for routine production of 18F-labelled radiopharmaceuticals, only a few reports1,2,3 have been published on theExpand
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