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SMAD4 wt Allele

Known as: SMAD, Mothers Against DPP Homolog 4 (Drosophila) wt Allele, SMAD4/DPC4 Gene, DPC4 
Human SMAD4 wild-type allele is located in the vicinity of 18q21.1 and is approximately 50 kb in length. This allele, which encodes mothers against… Expand
National Institutes of Health

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Highly Cited
2004
Highly Cited
2004
BACKGROUND Juvenile polyposis and hereditary haemorrhagic telangiectasia are autosomal dominant disorders with distinct and non… Expand
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Highly Cited
2002
Highly Cited
2002
It is estimated that familial aggregation and genetic susceptibility play a role in as many as 10% of pancreatic ductal… Expand
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Highly Cited
2000
Highly Cited
2000
Infiltrating adenocarcinomas of the pancreas are believed to arise from histologically identifiable intraductal precursors… Expand
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Highly Cited
2000
Highly Cited
2000
DPC4 (MADH4, SMAD4) encodes a nuclear transcription factor shown to be genetically inactivated in over one-half of conventional… Expand
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Highly Cited
2000
Highly Cited
2000
DPC4 (MADH4, SMAD4) is a tumor suppressor gene inactivated by allelic loss in approximately 55% of pancreatic adenocarcinomas… Expand
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Highly Cited
2000
Highly Cited
2000
DPC4 (MADH4, SMAD4) is a nuclear transcription factor shown to be genetically inactivated in over half of infiltrating ductal… Expand
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Highly Cited
1997
Highly Cited
1997
During tumorigenesis, positive selection is exerted upon those tumor cells that alter rate-limiting regulatory pathways. A… Expand
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Highly Cited
1997
Highly Cited
1997
Allelic deletions of chromosome 18q are reported to be common in prostate and colorectal cancers, suggesting that one or more… Expand
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Highly Cited
1996
Highly Cited
1996
BACKGROUND & AIMS The chromosome region 18q21 has been shown to be frequently deleted in colorectal cancers, and such frequent… Expand
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Highly Cited
1996
Highly Cited
1996
Absolute genetic differences between neoplastic and nonneoplastic cells can be discerned at sites of homozygous deletions. These… Expand
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