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SMAD4 wt Allele

Known as: SMAD, Mothers Against DPP Homolog 4 (Drosophila) wt Allele, SMAD4/DPC4 Gene, DPC4 
Human SMAD4 wild-type allele is located in the vicinity of 18q21.1 and is approximately 50 kb in length. This allele, which encodes mothers against… 
National Institutes of Health

Related topics

Related topics

19 relations
18q21.1ALK PathwayAdenocarcinoma of ampulla of VaterCTCF Pathway

Broader (1)

SMAD4 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2006
2006
Mutation screening in juvenile polyposis syndrome.
Juvenile polyposis syndrome (JPS) is an autosomal dominant cancer predisposition syndrome characterized by congenital anomalies… 
Highly Cited
2005
Highly Cited
2005
Immunohistochemistry Can Help Distinguish Metastatic Pancreatic Adenocarcinomas From Bile Duct Adenomas and Hamartomas of the Liver
Not uncommonly, bile duct adenomas (BDAs) and hamartomas (BDHs) of the liver may be difficult to distinguish from metastatic well… 
2005
2005
A combination of molecular cytogenetic analyses reveals complex genetic alterations in conventional renal cell carcinoma.
2005
2005
MUC1 overexpression is the most reliable marker of invasive carcinoma in intraductal papillary-mucinous tumor (IPMT).
BACKGROUND/AIMS To clarify the development of pancreatic cancer we performed immunohistochemical analysis of the presence of the… 
2001
2001
Pancreatic intraepithelial neoplasia and infiltrating adenocarcinoma: analysis of progression and recurrence by DPC4 immunohistochemical labeling.
Pancreatic intraepithelial neoplasia (PanIN) is thought to be a precursor lesion of infiltrating pancreatic ductal adenocarcinoma… 
2000
2000
Homozygous deletions inactivate DCC, but not MADH4/DPC4/SMAD4, in a subset of pancreatic and biliary cancers
Loss of heterozygosity (LOH) of chromosome arm 18q is frequent in gastrointestinal cancers. Over 90% of pancreatic carcinomas… 
2000
2000
The 18q21 region in colorectal and pancreatic cancer: independent loss of DCC and DPC4 expression.
Highly Cited
1997
Highly Cited
1997
Allelic losses on 18q21 are associated with progression and metastasis in human prostate cancer
We analyzed normal/tumor DNA pairs obtained from 46 patients with prostate cancers (stage B, 16 cases; C, 10 cases; D1, 4 cases… 
1997
1997
Mapping of a Breast Cancer Tumor Suppressor Gene Locus to a 4‐cM Interval on Chromosome 18q21
DPC4 and DCC, putative tumor suppressor genes implicated in the genesis of several types of human cancer, lie on the long arm of… 
Highly Cited
1996
Highly Cited
1996
Infrequent DPC4 gene mutation in esophageal cancer, gastric cancer and ulcerative colitis-associated neoplasms.
Homozygously Deleted in Pancreatic Cancer 4 (DPC4), a recently identified candidate tumor suppressor gene, was previously shown… 
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