SMAD4 wt Allele

Known as: SMAD, Mothers Against DPP Homolog 4 (Drosophila) wt Allele, SMAD4/DPC4 Gene, DPC4 
Human SMAD4 wild-type allele is located in the vicinity of 18q21.1 and is approximately 50 kb in length. This allele, which encodes mothers against… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1996-2017
05101519962017

Papers overview

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Highly Cited
2009
Highly Cited
2009
PURPOSE Contrary to the extensive data accumulated regarding pancreatic carcinogenesis, the clinical and molecular features… (More)
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Highly Cited
2002
Highly Cited
2002
It is estimated that familial aggregation and genetic susceptibility play a role in as many as 10% of pancreatic ductal… (More)
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Highly Cited
2001
Highly Cited
2001
Juvenile polyposis (JP; OMIM 174900) is an autosomal dominant gastrointestinal hamartomatous polyposis syndrome in which patients… (More)
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Highly Cited
2001
Highly Cited
2001
The presumed precursor lesions of pancreatic ductal adenocarcinoma were recently classified according to their increasing grade… (More)
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Highly Cited
2000
Highly Cited
2000
Infiltrating adenocarcinomas of the pancreas are believed to arise from histologically identifiable intraductal precursors… (More)
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Highly Cited
1998
Highly Cited
1998
The DPC4 (SMAD4) gene plays a key role in the TGFbeta signaling pathway. We inactivated its mouse homolog Dpc4 (Smad4). The… (More)
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Highly Cited
1997
Highly Cited
1997
During tumorigenesis, positive selection is exerted upon those tumor cells that alter rate-limiting regulatory pathways. A… (More)
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Highly Cited
1996
Highly Cited
1996
About 90 percent of human pancreatic carcinomas show allelic loss at chromosome 18q. To identify candidate tumor suppressor genes… (More)
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Highly Cited
1996
Highly Cited
1996
We recently identified a novel tumor-suppressor gene, DPC4, at chromosome 18q21.1 and found that both alleles of DPC4 were… (More)
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Highly Cited
1996
Highly Cited
1996
THE TGF-β/activin/BMP superfamily of growth factors signals through heteromeric receptor complexes of type I and type II serine… (More)
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