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Comprehensive genomic characterization defines human glioblastoma genes and core pathways
The interim integrative analysis of DNA copy number, gene expression and DNA methylation aberrations in 206 glioblastomas reveals a link between MGMT promoter methylation and a hypermutator phenotype consequent to mismatch repair deficiency in treated gliobeasts, demonstrating that it can rapidly expand knowledge of the molecular basis of cancer.
Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.
- D. Brat, R. Verhaak, +304 authors Jianan Zhang
- Medicine, BiologyThe New England journal of medicine
- 25 June 2015
The integration of genomewide data from multiple platforms delineated three molecular classes of lower-grade gliomas that were more concordant with IDH, 1p/19q, and TP53 status than with histologic class.
The Immune Landscape of Cancer
An extensive immunogenomic analysis of more than 10,000 tumors comprising 33 diverse cancer types by utilizing data compiled by TCGA identifies six immune subtypes that encompass multiple cancer types and are hypothesized to define immune response patterns impacting prognosis.
Transforming Fusions of FGFR and TACC Genes in Human Glioblastoma
In mice, FGFR inhibitors slowed the growth of tumors driven by the TACC-FGFR gene, suggesting that a subset of glioblastoma patients may benefit from these types of drugs, and a fusion gene detected in a small subset of human brain tumors encodes a potentially druggable target.
The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis.
A precise definition of the mechanisms by which IL-8 exerts its proangiogenic functions requires further study for the development of effectiveIL-8-targeted therapies.
Microregional extracellular matrix heterogeneity in brain modulates glioma cell invasion.
- A. Bellail, S. Hunter, D. Brat, Chalet Tan, Erwin G. Van Meir
- Biology, MedicineThe international journal of biochemistry & cell…
- 1 June 2004
The impact of microregional heterogeneity of the ECM on glioma invasion in the normal adult brain and its modifications in tumoral brain is focused on.
Comprehensive Characterization of Cancer Driver Genes and Mutations
This study reports a PanCancer and PanSoftware analysis spanning 9,423 tumor exomes (comprising all 33 of The Cancer Genome Atlas projects) and using 26 computational tools to catalog driver genes and mutations, identifying 299 driver genes with implications regarding their anatomical sites and cancer/cell types.
Extraventricular Neurocytomas: Pathologic Features and Clinical Outcome
- D. Brat, B. Scheithauer, C. Eberhart, P. Burger
- MedicineThe American journal of surgical pathology
- 1 October 2001
The majority of EVNs are well differentiated and appear unlikely to recur after gross total resection, atypical histologic features, and high cell proliferation rates correlate with recurrence.
Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma
The complete set of genes associated with 1,122 diffuse grade II-III-IV gliomas were defined from The Cancer Genome Atlas and molecular profiles were used to improve disease classification, identify molecular correlations, and provide insights into the progression from low- to high-grade disease.
Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis.
- B. Kaur, F. Khwaja, E. Severson, S. Matheny, D. Brat, Erwin G. Van Meir
- Biology, MedicineNeuro-oncology
- 1 April 2005
Hypoxia-inducible factor 1 (HIF-1) is a critical regulatory factor in the tumor microenvironment because of its central role in promoting proangiogenic and invasive properties.