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The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient’s clinical history and other diagnostic tests by a qualified pathologist. Expand
A germline DNA polymorphism enhances alternative splicing of the KLF6 tumor suppressor gene and is associated with increased prostate cancer risk.
These results are the first to identify a novel mechanism of self-encoded tumor suppressor gene inactivation and link a relatively common single nucleotide polymorphism to both regulation of alternative splicing and an increased risk in a major human cancer. Expand
Tumor-associated zinc finger mutations in the CTCF transcription factor selectively alter tts DNA-binding specificity.
CTCF is a widely expressed 11-zinc finger (ZF) transcription factor that is involved in different aspects of gene regulation including promoter activation or repression, hormone-responsive gene… Expand
Neuroendocrine differentiation in the progression of prostate cancer
- A. Komiya, Hiroyoshi Suzuki, +5 authors H. Fuse
- International journal of urology : official…
- 1 January 2009
In metastatic PCa, pretreatment serum CGA levels can be a predictor for progression and survival after endocrine therapy, and it is recommended to measure longitudinal change in serum C GA. Expand
Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk
The results of genetic analyses indicate that mutations in MSR1 may be associated with risk of prostate cancer in men of both African American and European descent and show that MSR 1 may be important in susceptibility to prostate cancer. Expand
Common sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk.
Five common variants of MSR1 are studied in patients with non-HPC who underwent prostate cancer treatment and in control subjects who participated in prostate cancer-screening programs and had normal digital rectal examination and PSA levels. Expand
Codon 877 Mutation in the Androgen Receptor Gene in Advanced Prostate Cancer: Relation to Antiandrogen Withdrawal Syndrome
- H. Suzuki, K. Akakura, A. Komiya, S. Aida, S. Akimoto, J. Shimazaki
- Biology, Medicine
- The Prostate
- 1 September 1996
The results indicate that a codon 877 mutation in the AR gene in advanced prostate cancer evokes the antiandrogen withdrawal syndrome and that the mutation is found in relation to endocrine therapy resistance. Expand
Pretreatment serum testosterone level as a predictive factor of pathological stage in localized prostate cancer patients treated with radical prostatectomy.
A lower pretreatment T level appears to be predictive of extraprostatic disease in patients with localized prostate cancer, and pathological Gleason score, pretreatment serum T level and pretreatment PSA were significant predictors of extraProstatic disease. Expand
Localization of a tumor suppressor gene associated with progression of human prostate cancer within a 1.2 Mb region of 8p22‐p21.3
High‐resolution deletion mapping in 46 prostate cancers suggests that inactivation of tumor suppressor genes on 8p plays an important role in the progression of prostate cancer. Expand
Three distinct commonly deleted regions of chromosome arm 16q in human primary and metastatic prostate cancers
- H. Suzuki, A. Komiya, +4 authors J. Shimazaki
- Biology, Medicine
- Genes, chromosomes & cancer
- 1 December 1996
The results suggest that inactivation of tumor suppressor genes on 16q plays an important role in the progression of prostate cancer. Expand