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SMAD4 gene

Known as: DELETED IN PANCREATIC CARCINOMA 4, DPC4, SMAD family member 4 
This gene plays a role in signal transduction and transcriptional activation. It is also involved in suppression of angiogenesis.
National Institutes of Health

Related topics

Related topics

18 relations
Adenocarcinoma of ampulla of VaterAmpulla of Vater Pancreatobiliary Type AdenocarcinomaColloid Carcinoma of the PancreasJuvenile polyposis syndrome

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SMAD4 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
TGF‐β signaling directly regulates transcription and functional expression of the electrogenic sodium bicarbonate cotransporter 1, NBCe1 (SLC4A4), via Smad4 in mouse astrocytes
The electrogenic sodium bicarbonate cotransporter NBCe1 (SLC4A4) expressed in astrocytes regulates intracellular and… 
2006
2006
Mutation screening in juvenile polyposis syndrome.
Juvenile polyposis syndrome (JPS) is an autosomal dominant cancer predisposition syndrome characterized by congenital anomalies… 
2001
2001
Exclusion of SMAD4 mutation as an early genetic change in human pancreatic ductal tumorigenesis
Pancreatic ductal carcinoma is one of the malignant diseases with the poorest prognosis. To develop effective methods for better… 
2001
2001
Pancreatic intraepithelial neoplasia and infiltrating adenocarcinoma: analysis of progression and recurrence by DPC4 immunohistochemical labeling.
Pancreatic intraepithelial neoplasia (PanIN) is thought to be a precursor lesion of infiltrating pancreatic ductal adenocarcinoma… 
1999
1999
Chromosome 18 breakpoint in t(11;18)(q21;q21) translocation associated with MALT lymphoma is proximal to BCL2 and distal to DCC
The t(11;18)(q21;q21) translocation has recently been identified as a recurring chromosomal abnormality in a subset of extranodal… 
1999
1999
Molecular genetics and related developments in pancreatic cancer.
Cancer of the pancreas is a genetic disease. The most common genetic alterations identified to date in pancreatic cancer are… 
Highly Cited
1997
Highly Cited
1997
Allelic losses on 18q21 are associated with progression and metastasis in human prostate cancer
We analyzed normal/tumor DNA pairs obtained from 46 patients with prostate cancers (stage B, 16 cases; C, 10 cases; D1, 4 cases… 
Highly Cited
1997
Highly Cited
1997
Evidence that loss of chromosome 18q is associated with tumor progression.
Four sets of cell lines (UM-SCC-14A, -14B, and -14C; UM-SCC-17A and -17B; UM-SCC-81A and -81B; and UM-SCC-83A and -83B… 
1997
1997
Mapping of a Breast Cancer Tumor Suppressor Gene Locus to a 4‐cM Interval on Chromosome 18q21
DPC4 and DCC, putative tumor suppressor genes implicated in the genesis of several types of human cancer, lie on the long arm of… 
Review
1997
Review
1997
Molecular diagnosis of pancreas carcinoma
  • T. Chu
  • Journal of clinical laboratory analysis (Print)
  • 1997
  • Corpus ID: 43587823
Cellular protooncogenes, tumor suppressor genes (antioncogenes), and DNA mismatch repair mutators are generally the key molecular… 
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