SMAD4 gene

Known as: DELETED IN PANCREATIC CARCINOMA 4, DPC4, SMAD family member 4 
This gene plays a role in signal transduction and transcriptional activation. It is also involved in suppression of angiogenesis.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1981-2018
05010019812018

Papers overview

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Review
2015
Review
2015
Colorectal cancer (CRC) is one of the most common cancers in the western world and is characterised by deregulation of the Wnt… (More)
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Highly Cited
2012
Highly Cited
2012
Pancreatic cancer is a highly lethal malignancy with few effective therapies. We performed exome sequencing and copy number… (More)
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Highly Cited
2011
Highly Cited
2011
Effective clinical management of prostate cancer (PCA) has been challenged by significant intratumoural heterogeneity on the… (More)
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Highly Cited
2009
Highly Cited
2009
PURPOSE Recently, the majority of protein coding genes were sequenced in a collection of pancreatic cancers, providing an… (More)
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Highly Cited
2005
Highly Cited
2005
Hereditary hemochromatosis, characterized by iron overload in multiple organs, is one of the most common genetic disorders among… (More)
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Highly Cited
2004
Highly Cited
2004
BACKGROUND Juvenile polyposis and hereditary haemorrhagic telangiectasia are autosomal dominant disorders with distinct and non… (More)
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Highly Cited
1998
Highly Cited
1998
Familial juvenile polyposis is an autosomal dominant disease characterized by a predisposition to hamartomatous polyps and… (More)
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Highly Cited
1998
Highly Cited
1998
The DPC4 (SMAD4) gene plays a key role in the TGFbeta signaling pathway. We inactivated its mouse homolog Dpc4 (Smad4). The… (More)
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Highly Cited
1998
Highly Cited
1998
Members of the transforming growth factor (TGF)-beta superfamily have been shown to play a variety of important roles in… (More)
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Highly Cited
1996
Highly Cited
1996
About 90 percent of human pancreatic carcinomas show allelic loss at chromosome 18q. To identify candidate tumor suppressor genes… (More)
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