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SMAD4 gene

Known as: DELETED IN PANCREATIC CARCINOMA 4, DPC4, SMAD family member 4 
This gene plays a role in signal transduction and transcriptional activation. It is also involved in suppression of angiogenesis.
National Institutes of Health

Related topics

Related topics

18 relations
Adenocarcinoma of ampulla of VaterAmpulla of Vater Pancreatobiliary Type AdenocarcinomaColloid Carcinoma of the PancreasJuvenile polyposis syndrome

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SMAD4 wt Allele

Papers overview

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Highly Cited
2005
Highly Cited
2005
Immunohistochemistry Can Help Distinguish Metastatic Pancreatic Adenocarcinomas From Bile Duct Adenomas and Hamartomas of the Liver
Not uncommonly, bile duct adenomas (BDAs) and hamartomas (BDHs) of the liver may be difficult to distinguish from metastatic well… 
Highly Cited
2005
Highly Cited
2005
A complex pattern of mutations and abnormal splicing of Smad4 is present in thyroid tumours
Sensitivity to transforming growth factor-β is impaired in thyroid tumours. Similar to Mad – Mother Against Decapentaplegic-(Smad… 
Highly Cited
2004
Highly Cited
2004
Intraductal Tubular Adenoma, Pyloric Type, of the Pancreas: Additional Observations on a New Type of Pancreatic Neoplasm
Three cases of a distinctive intraductal tubular adenoma, pyloric type, of the main pancreatic duct are reported. The patients… 
Highly Cited
2003
Highly Cited
2003
Differential regulation of TGF-β signaling through Smad2, Smad3 and Smad4
Smad transcription factors mediate the growth inhibitory effect of transforming growth factor-β (TGF-β) in many cell types… 
Highly Cited
2001
Highly Cited
2001
Overexpression of Smad2 reveals its concerted action with Smad4 in regulating TGF-beta-mediated epidermal homeostasis.
Members of the transforming growth factor-beta (TGF-beta) superfamily are critical regulators for epithelial growth and can alter… 
2000
2000
A novel SMAD4 gene mutation in seminoma germ cell tumors.
Transforming growth factor (TGF)-beta is known as an antiproliferative factor in the majority of mammalian cells, including stem… 
Highly Cited
1998
Highly Cited
1998
Interplay of signal mediators of decapentaplegic (Dpp): molecular characterization of mothers against dpp, Medea, and daughters against dpp.
Decapentaplegic (Dpp) plays an essential role in Drosophila development, and analyses of the Dpp signaling pathway have… 
Highly Cited
1997
Highly Cited
1997
Allelic losses on 18q21 are associated with progression and metastasis in human prostate cancer
We analyzed normal/tumor DNA pairs obtained from 46 patients with prostate cancers (stage B, 16 cases; C, 10 cases; D1, 4 cases… 
Highly Cited
1997
Highly Cited
1997
Evidence that loss of chromosome 18q is associated with tumor progression.
Four sets of cell lines (UM-SCC-14A, -14B, and -14C; UM-SCC-17A and -17B; UM-SCC-81A and -81B; and UM-SCC-83A and -83B… 
Highly Cited
1996
Highly Cited
1996
Infrequent DPC4 gene mutation in esophageal cancer, gastric cancer and ulcerative colitis-associated neoplasms.
Homozygously Deleted in Pancreatic Cancer 4 (DPC4), a recently identified candidate tumor suppressor gene, was previously shown… 
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