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SMAD4 protein, human

Known as: DPC4 Protein, SMA- and MAD-Related Protein 4, MAD4 
The SMAD4 tumor suppressor protein specifically recognizes an eight base pair palindromic DNA sequence and is critical for transmitting TGFB, and… 
National Institutes of Health

Related topics

Related topics

18 relations
ALK PathwayCTCF PathwayCell CycleG1/S Checkpoint Pathway

Broader (2)

ProteinsSmad4 Protein

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Dissecting the complex regulation of Mad4 in glioblastoma multiforme cells
Among proteins in the c-Myc/Max/Mad/Sin3 regulatory complex, Mad4 and Sin3B are routinely detected in human glioblastoma… 
2009
2009
[Analysis of K-ras, BRCA1/2, CHEK2 mutations and microsatellite markers (loss of heterozygosity at 9p, 17p and 18q) in sporadic pancreas adenocarcinomas].
The purpose of this study was to investigate informativety and clinical significance of most frequent somatic alterations in K… 
2008
2008
In vitro differential sensitivity of melanomas to phenothiazines is based on the presence of codon 600 BRAF mutation
The panel of 60 human cancer cell lines (the NCI-60) assembled by the National Cancer Institute for anticancer drug discovery is… 
2005
2005
An unexpected Cowden syndrome case found among members of a large familial adenomatous polyposis kindred.
Genetic testing is now considered the standard of care in the management of familial adenomatous polyposis (FAP). Non-carriers of… 
Highly Cited
2003
Highly Cited
2003
Mad4 is regulated by a transcriptional repressor complex that contains Miz-1 and c-Myc.
Myc and Mad family proteins are central regulators of cellular proliferation and differentiation. We show that various Mad family… 
2003
2003
hMad4, c‐Myc endogenous inhibitor, induces a replicative senescence‐like state when overexpressed in human fibroblasts
Mad family proteins have an antagonistic action on Myc‐dependent cell proliferation and transformation. We isolated a human cDNA… 
2001
2001
Analysis of human meningiomas for aberrations of the MADH2, MADH4, APM‐1 and DCC tumor suppressor genes on the long arm of chromosome 18
We have previously reported that losses of genomic material from the long arm of chromosome 18 are frequent in atypical and… 
2000
2000
Homozygous deletions inactivate DCC, but not MADH4/DPC4/SMAD4, in a subset of pancreatic and biliary cancers
Loss of heterozygosity (LOH) of chromosome arm 18q is frequent in gastrointestinal cancers. Over 90% of pancreatic carcinomas… 
1997
1997
Sequence and chromosomal mapping of the mouse homolog (Madh4) of the human DPC4/MADH4 gene
The human DPC4/MADH4 gene was recently sequenced and mapped to Chr 18q21.1 [Hahn et al. 1996b]. It appears to be a target for… 
Review
1997
Review
1997
Cytokine-induced inhibition of Myc activity in monocytic cells.
The c-myc proto-oncogene plays an important role in the regulation of cell proliferation, differentiation and apoptosis. It… 
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