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SMAD2 protein, human

Known as: SMA- and MAD-Related Protein 2, Mothers Against Decapentaplegic Homolog 2 Protein, Mothers Against DPP Homolog 2 
Mothers against decapentaplegic homolog 2 (467 aa, ~52 kDa) is encoded by the human SMAD2 gene. This protein plays a role in signal transduction and… 
National Institutes of Health

Related topics

Related topics

20 relations
Adaptor Signaling Protein GeneCell CycleCell Differentiation processCell Nucleus

Broader (1)

SMAD2 protein

Papers overview

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Highly Cited
2012
Highly Cited
2012
Diketopyrrolopyrrole-diketopyrrolopyrrole-based conjugated copolymer for high-mobility organic field-effect transistors.
In this communication, we report the synthesis of a novel diketopyrrolopyrrole-diketopyrrolopyrrole (DPP-DPP)-based conjugated… 
Highly Cited
2010
Highly Cited
2010
Smad2 protects against TGF-beta/Smad3-mediated renal fibrosis.
Smad2 and Smad3 interact and mediate TGF-beta signaling. Although Smad3 promotes fibrosis, the role of Smad2 in fibrogenesis is… 
Highly Cited
2003
Highly Cited
2003
TGF-beta1-mediated fibroblast-myofibroblast terminal differentiation-the role of Smad proteins.
Highly Cited
2002
Highly Cited
2002
Metastasis is driven by sequential elevation of H-ras and Smad2 levels
Metastasis is a multistep process that involves local tumour invasion followed by dissemination to, and re-establishment at… 
Highly Cited
2001
Highly Cited
2001
Crystal structure of a phosphorylated Smad2. Recognition of phosphoserine by the MH2 domain and insights on Smad function in TGF-beta signaling.
Highly Cited
2001
Highly Cited
2001
TGF-β induces assembly of a Smad2–Smurf2 ubiquitin ligase complex that targets SnoN for degradation
The receptor-regulated Smad proteins are essential intracellular mediators of signal transduction by the transforming growth… 
Highly Cited
2000
Highly Cited
2000
Smurf2 Is a Ubiquitin E3 Ligase Mediating Proteasome-dependent Degradation of Smad2 in Transforming Growth Factor-β Signaling* 210
Smads are important intracellular signaling effectors for transforming growth factor-β (TGF-β) and related factors. Proper TGF… 
Highly Cited
2000
Highly Cited
2000
Transforming Growth Factor β-Independent Shuttling of Smad4 between the Cytoplasm and Nucleus
ABSTRACT Smad4 plays a pivotal role in all transforming growth factor β (TGF-β) signaling pathways. Here we describe six widely… 
Highly Cited
1998
Highly Cited
1998
Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2.
smad genes constitute a family of nine members whose products serve as intracellular mediators of transforming growth factor beta… 
Highly Cited
1997
Highly Cited
1997
TβRI Phosphorylation of Smad2 on Ser465 and Ser467 Is Required for Smad2-Smad4 Complex Formation and Signaling*
Mothers against Dpp-related or Smad proteins are essential components of serine/threonine kinase receptor signaling pathways that… 
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