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A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis
TLDR
It is shown that Sirt3 functions in vivo to regulate and maintain basal ATP levels and as a regulator of mitochondrial electron transport and implicate protein acetylation as an important regulator of Complex I activity.
Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon
TLDR
Observations point to a potential oncogenic role for YAP in 11q22-amplified human cancers, and suggest that this highly conserved signaling pathway identified in Drosophila regulates both cellular proliferation and apoptosis in mammalian epithelial cells.
Silencing of unsynapsed meiotic chromosomes in the mouse
TLDR
It is shown that silencing of unpaired (unsynapsed) chromosome regions also takes place in the mouse during both male and female meiosis, which impacts on the interpretation of the relationship between synaptic errors and sterility in mammals and extends the understanding of the biology of Brca1.
Recent progress in the biology and physiology of sirtuins
TLDR
The recent progress in sirtuin biology, the role these proteins have in various age-related diseases and the tantalizing notion that the activity of this family of enzymes somehow regulates how long the authors live are reviewed.
Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation
TLDR
It is demonstrated that disruption of Brca1 causes genetic instability and triggers further alterations, including the inactivation of p53, that lead to tumour formation.
Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction.
TLDR
Findings provide direct genetic evidence that FGF/FGFR2 signals are absolutely required for vertebrate limb induction and that an FGFR2 signal is essential for the reciprocal regulation loop between FGF8 and FGF10 during limb induction.
Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation.
TLDR
The data reveal Edg-1 to be the first G protein-coupled receptor required for blood vessel formation and show that sphingolipid signaling is essential during mammalian development.
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