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SLC47A1 wt Allele

Known as: MATE1, MATE-1, hMATE-1 
Human SLC47A1 wild-type allele is located in the vicinity of 17p11.2 and is approximately 84 kb in length. This allele, which encodes multidrug and… 
National Institutes of Health

Related topics

Related topics

7 relations
Homo sapiensIonophore activityLigand BindingMolecular Transport

Papers overview

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Highly Cited
2015
Highly Cited
2015
Metabolism and Disposition of Cabozantinib in Healthy Male Volunteers and Pharmacologic Characterization of Its Major Metabolites
Metabolism and excretion of cabozantinib, an oral inhibitor of receptor tyrosine kinases, was studied in 8 healthy male… 
Highly Cited
2013
Highly Cited
2013
A gene–gene interaction between polymorphisms in the OCT2 and MATE1 genes influences the renal clearance of metformin
Objective The aim of this study was to determine the association between the renal clearance (CLrenal) of metformin in healthy… 
Highly Cited
2013
Highly Cited
2013
Prediction of clinical drug-drug interactions of veliparib (ABT-888) with human renal transporters (OAT1, OAT3, OCT2, MATE1, and MATE2K).
Veliparib (ABT-888) is largely eliminated as parent drug in human urine (70% of the dose). Renal unbound clearance exceeds… 
Highly Cited
2013
Highly Cited
2013
Role of organic cation transporter OCT2 and multidrug and toxin extrusion proteins MATE1 and MATE2-K for transport and drug interactions of the antiviral lamivudine.
Highly Cited
2010
Highly Cited
2010
Heterozygous variants of multidrug and toxin extrusions (MATE1 and MATE2-K) have little influence on the disposition of metformin in diabetic patients.
Multidrug and toxin extrusions (MATE1/SLC47A1 and MATE2-K/SLC47A2) play important roles in the renal excretion of metformin. We… 
Highly Cited
2009
Highly Cited
2009
Identification and characterization of novel polymorphisms in the basal promoter of the human transporter, MATE1
Objectives Human multidrug and toxin extrusion member 1, MATE1 (SLC47A1), plays an important role in the renal and biliary… 
Highly Cited
2009
Highly Cited
2009
Protective effect of concomitant administration of imatinib on cisplatin-induced nephrotoxicity focusing on renal organic cation transporter OCT2.
Highly Cited
2008
Highly Cited
2008
Tissue distribution, ontogeny and induction of the transporters Multidrug and toxin extrusion (MATE) 1 and MATE2 mRNA expression levels in mice.
2007
2007
Molecular identification and functional characterization of rabbit MATE1 and MATE2
An electroneutral organic cation‐proton exchanger in the apical membrane of proximal tubules mediates the final step of renal… 
Highly Cited
2006
Highly Cited
2006
Molecular Cloning, Functional Characterization and Tissue Distribution of Rat H+/Organic Cation Antiporter MATE1
PurposeTransport characteristics and tissue distribution of the rat H+/organic cation antiporter MATE1 (multidrug and toxin… 
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