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Identification and functional characterization of a new human kidney-specific H+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2.
- S. Masuda, T. Terada, +5 authors K. Inui
- Biology, Medicine
- Journal of the American Society of Nephrology…
- 1 August 2006
A cDNA coding a new H+/organic cation antiporter, human kidney-specific multidrug and toxin extrusion 2 (hMATE2-K), has been isolated from the human kidney. The hMATE2-K cDNA had an open reading… Expand
Cisplatin and Oxaliplatin, but Not Carboplatin and Nedaplatin, Are Substrates for Human Organic Cation Transporters (SLC22A1–3 and Multidrug and Toxin Extrusion Family)
- A. Yonezawa, S. Masuda, Sachiko Yokoo, T. Katsura, K. Inui
- Chemistry, Medicine
- Journal of Pharmacology and Experimental…
- 1 November 2006
We have examined the role of the human organic cation transporters [hOCTs and human novel organic cation transporter (hOCTN); SLC22A1–5] and apical multidrug and toxin extrusion (hMATE) in the… Expand
Differential contribution of organic cation transporters, OCT2 and MATE1, in platinum agent-induced nephrotoxicity.
- Sachiko Yokoo, A. Yonezawa, S. Masuda, A. Fukatsu, T. Katsura, K. Inui
- Chemistry, Medicine
- Biochemical pharmacology
- 1 August 2007
The mechanism of severe nephrotoxicity caused by cisplatin, but not carboplatin, oxaliplatin, and nedaplatin, is not fully understood. The renal accumulation and subsequent nephrotoxicity of platinum… Expand
Importance of the multidrug and toxin extrusion MATE/SLC47A family to pharmacokinetics, pharmacodynamics/toxicodynamics and pharmacogenomics
- A. Yonezawa, K. Inui
- Biology, Medicine
- British journal of pharmacology
- 1 December 2011
The renal organic cation transport system mediates the tubular secretion of cationic compounds including drugs, toxins and endogenous metabolites into urine. It consists of a membrane… Expand
Nicotinic Acetylcholine Receptor-Mediated Neuroprotection by Donepezil Against Glutamate Neurotoxicity in Rat Cortical Neurons
- Y. Takada, A. Yonezawa, +4 authors A. Akaike
- Chemistry, Medicine
- Journal of Pharmacology and Experimental…
- 1 August 2003
Donepezil is a potent and selective acetylcholinesterase (AChE) inhibitor developed for the treatment of Alzheimer's disease. To elucidate whether donepezil shows neuroprotective action in addition… Expand
Disruption of multidrug and toxin extrusion MATE1 potentiates cisplatin-induced nephrotoxicity.
- T. Nakamura, A. Yonezawa, S. Hashimoto, T. Katsura, K. Inui
- Chemistry, Medicine
- Biochemical pharmacology
- 1 December 2010
Multidrug and toxin extrusion 1 (MATE1/SLC47A1) is expressed in the brush-border membrane of renal proximal tubules and mediates the efflux of cationic drugs. In the present study, the role of MATE1… Expand
Maternal riboflavin deficiency, resulting in transient neonatal‐onset glutaric aciduria Type 2, is caused by a microdeletion in the riboflavin transporter gene GPR172B
- G. Ho, A. Yonezawa, +8 authors J. Christodoulou
- Biology, Medicine
- Human mutation
- 1 January 2011
Riboflavin, or vitamin B2, is a precursor to flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) molecules, required in biological oxidation‐reduction reactions. We previously reported… Expand
Novel riboflavin transporter family RFVT/SLC52: identification, nomenclature, functional characterization and genetic diseases of RFVT/SLC52.
- A. Yonezawa, K. Inui
- Biology, Medicine
- Molecular aspects of medicine
- 1 April 2013
Riboflavin, a water-soluble vitamin also known as vitamin B2, is essential for normal cellular functions. Riboflavin transporters play important roles in its homeostasis. Recently, three novel… Expand
Transcellular transport of organic cations in double-transfected MDCK cells expressing human organic cation transporters hOCT1/hMATE1 and hOCT2/hMATE1.
- Tomoko Sato, S. Masuda, A. Yonezawa, Y. Tanihara, T. Katsura, K. Inui
- Chemistry, Medicine
- Biochemical pharmacology
- 1 October 2008
To clarify the transcellular transport of organic cations via basolateral and apical transporters, we established double-transfected Madin-Darby canine kidney (MDCK) cells expressing both human… Expand
Organic cation transporter OCT/SLC22A and H(+)/organic cation antiporter MATE/SLC47A are key molecules for nephrotoxicity of platinum agents.
- A. Yonezawa, K. Inui
- Chemistry, Medicine
- Biochemical pharmacology
- 1 March 2011
Platinum agents have been widely used in cancer chemotherapy for a long time. Cisplatin, carboplatin, oxaliplatin and nedaplatin have a common chemical structure consisting of platinum, carrier… Expand