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SLC3A2 wt Allele

Known as: CD98, 4F2, Solute Carrier Family 3 (Activators of Dibasic And Neutral Amino Acid Transport), Member 2 Gene 
Human SLC3A2 wild-type allele is located in the vicinity of 11q13 and is approximately 33 kb in length. This allele, which encodes 4F2 cell-surface… 
National Institutes of Health

Related topics

Related topics

6 relations
11q13Homo sapiensIonophore activityLigand Binding

Papers overview

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Highly Cited
2001
Highly Cited
2001
Expression of L‐type amino acid transporter 1 (LAT1) and 4F2 heavy chain (4F2hc) in liver tumor lesions of rat models
It has been said that amino acid transporters play an important role in supplying nutrition to cells and for cell proliferation… 
2000
2000
Enhanced tumorigenicity caused by truncation of the extracellular domain of GP125/CD98 heavy chain
GP125/CD98 is a heterodimeric 125-kDa glycoprotein, which consists of an 85-kDa heavy chain (hc) and a 40-kDa light chain (lc… 
Highly Cited
1999
Highly Cited
1999
Cloning and Expression of a b0,+-like Amino Acid Transporter Functioning as a Heterodimer with 4F2hc Instead of rBAT
We have cloned a transporter protein from rabbit small intestine, which, when coexpressed with the 4F2 heavy chain (4F2hc) in… 
Highly Cited
1995
Highly Cited
1995
The amino acid transport system y+L induced in Xenopus laevis oocytes by human choriocarcinoma cell (JAR) mRNA is functionally related to the heavy chain of the 4F2 cell surface antigen.
Injection of mRNA isolated from human placental choriocarcinoma cells (JAR) into Xenopus laevis oocytes induced the transport of… 
Highly Cited
1995
Highly Cited
1995
The 4F2hc surface antigen is necessary for expression of system L-like neutral amino acid-transport activity in C6-BU-1 rat glioma cells: evidence from expression studies in Xenopus laevis oocytes.
Mammalian cells possess a variety of amino acid-transport systems with overlapping substrate specificity. System L is one of the… 
Highly Cited
1992
Highly Cited
1992
The 4F2 antigen heavy chain induces uptake of neutral and dibasic amino acids in Xenopus oocytes.
Highly Cited
1989
Highly Cited
1989
The first intron of the 4F2 heavy-chain gene contains a transcriptional enhancer element that binds multiple nuclear proteins
We utilized the human 4F2 heavy-chain (4F2HC) gene as a model system to study the regulation of inducible gene expression during… 
1988
1988
Regulation of 4F2 heavy-chain gene expression during normal human T-cell activation can be mediated by multiple distinct molecular mechanisms
The 4F2 molecule belongs to the set of cell surface antigens which is induced following lectin- or antigen-mediated T-cell… 
1987
1987
Cloning, sequence analysis, and expression of the large subunit of the human lymphocyte activation antigen 4F2.
Among the earliest expressed antigens on the surface of activated human lymphocytes is the surface antigen 4F2. We have used DNA… 
1983
1983
Chromosome mapping of human cell surface molecules: Monoclonal anti-human lymphocyte antibodies 4F2, A3D8, and A1G3 define antigens controlled by different regions of chromosome 11
Monoclonal antibodies 4F2, A3D8, and A1G3, directed against cell surface antigens present on subsets of human cells, were used to… 
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