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The insulin-like growth factor (IGF-I) signalling pathway is essential for metabolism, cell growth and survival. It induces… Expand The life span of model organisms can be modulated by environmental conditions that influence cellular metabolism, oxidation, or… Expand The insulin/insulin-like growth factor (IGF) signaling pathway to mTOR is essential for the survival and growth of normal cells… Expand Eukaryotes have evolved elaborate mechanisms to survive periods of adversity. By manipulating genes that control these mechanisms… Expand A model for replicative life span extension by calorie restriction (CR) in yeast has been proposed whereby reduced glucose in the… Expand ABSTRACT The Saccharomyces cerevisiae Sir2 protein is an NAD+-dependent histone deacetylase (HDAC) that functions in… Expand Calorie restriction extends lifespan in a broad range of organisms, from yeasts to mammals. Numerous hypotheses have been… Expand The formation of complexes between proteins and ligands is fundamental to biological processes at the molecular level… Expand The Sir2 protein is an NAD(+)-dependent protein deacetylase that is required for silencing at the silent mating-type loci… Expand Nicotinamidase (NAMase) from the budding yeast, Saccharomyces cerevisiae, was purified by Ni2+ affinity chromatography and gel… Expand