• Publications
  • Influence
Mss51p and Cox14p jointly regulate mitochondrial Cox1p expression in Saccharomyces cerevisiae
TLDR
Evidence is presented showing that Cox1p synthesis is reduced in most COX mutants but is restored to that of wild type by the same mss51 mutation that suppresses shy1 mutants, which is proposed to form a transient Cox14p–Cox1p–Mss51p complex to downregulate Cox 1p synthesis. Expand
Cytochrome c release and mitochondria involvement in programmed cell death induced by acetic acid in Saccharomyces cerevisiae.
TLDR
The understanding of the involvement of a mitochondria-dependent apoptotic pathway in S. cerevisiae PCD process will be most useful in the further elucidation of an ancestral pathway common to PCD in metazoans. Expand
Regulation of yeast chronological life span by TORC1 via adaptive mitochondrial ROS signaling.
TLDR
It is shown that yeast strains with reduced target of rapamycin (TOR) signaling have greater overall mitochondrial electron transport chain activity during growth that is efficiently coupled to ATP production, which supplies an adaptive signal duringgrowth that extends chronological life span (CLS). Expand
Biogenesis and assembly of eukaryotic cytochrome c oxidase catalytic core.
TLDR
The current state of knowledge of the biogenesis and assembly of the eukaryotic COX catalytic core is reviewed and the degree of conservation of the players and mechanisms operating from yeast to human is discussed. Expand
Shy1p is necessary for full expression of mitochondrial COX1 in the yeast model of Leigh's syndrome
TLDR
It is proposed that Shy1p promotes the formation of an assembly intermediate in which Cox1 is one of the partners of COX, and the rates of synthesis and turnover of the mitochondrial translation products in wild‐type, mutant and revertant cells are compared. Expand
Mitochondrial respiratory thresholds regulate yeast chronological life span and its extension by caloric restriction.
TLDR
It is concluded that mitochondrial respiratory thresholds regulate yeast CLS and its extension by caloric restriction by increasing stress resistance, an important component of which is the optimal accumulation and mobilization of nutrient stores. Expand
In vivo and in organello assessment of OXPHOS activities.
TLDR
A set of accurate polarographic and spectrophotometric assays that use relatively small amounts of biological material and discuss the biochemical parameters appropriate for discriminating partial OXPHOS defects are described. Expand
Evaluation of the Mitochondrial Respiratory Chain and Oxidative Phosphorylation System Using Polarography and Spectrophotometric Enzyme Assays
TLDR
The assays described describe methods that form a biochemical characterization of the OXPHOS system in cells and mitochondria isolated from cultured cells or tissues. Expand
Titrating the Effects of Mitochondrial Complex I Impairment in the Cell Physiology*
TLDR
A quantitative correlation between the level of CI impairment and cell respiration, cell growth, free radical production, lipid peroxidation, mitochondrial membrane potential, and apoptosis was observed and it was showed that cell death was quantitatively associated with freeradical production rather than with a decrease in respiratory chain function. Expand
Cox25 Teams Up with Mss51, Ssc1, and Cox14 to Regulate Mitochondrial Cytochrome c Oxidase Subunit 1 Expression and Assembly in Saccharomyces cerevisiae*
TLDR
Evidence is presented showing that Cox25 is a new essential COX assembly factor that plays some roles similar to Cox14, an inner mitochondrial membrane intrinsic protein with a hydrophilic C terminus protruding into the matrix that is an essential component of the complexes containing newly synthesized Cox1, Ssc1, Mss51, and Cox14. Expand
...
1
2
3
4
5
...