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Photoreceptor-specific nuclear receptor NR2E3 functions as a transcriptional activator in rod photoreceptors.
NR2E3, a photoreceptor-specific orphan nuclear receptor, is believed to play a pivotal role in the differentiation of photoreceptors. Mutations in the human NR2E3 gene and its mouse ortholog areExpand
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The Leucine Zipper of NRL Interacts with the CRX Homeodomain
Photoreceptor-specific expression of rhodopsin is mediated by multiple cis-acting elements in the proximal promoter region. NRL (neural retina leucine zipper) and CRX (cone rod homeobox) proteinsExpand
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A mutation in NRL is associated with autosomal dominant retinitis pigmentosa
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The Minimal Transactivation Domain of the Basic Motif-Leucine Zipper Transcription Factor NRL Interacts with TATA-binding Protein*
The basic motif-leucine zipper (bZIP) transcription factor NRL controls the expression of rhodopsin and other phototransduction genes and is a key mediator of photoreceptor differentiation. ToExpand
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Effects of anti-VEGF treatment on the recovery of the developing retina following oxygen-induced retinopathy.
PURPOSE Inhibition of VEGF is widely used in patients to control neovascularization and decrease vascular permeability. To date, the effect of VEGF inhibition has not been evaluated in the developingExpand
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Mechanical stretch alters the actin cytoskeletal network and signal transduction in human trabecular meshwork cells.
PURPOSE Human trabecular meshwork (HTM) cells were mechanically stretched in vitro as a potential model for the distension of this tissue that can occur in vivo in response to increased pressureExpand
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Epigenetic regulatory mechanisms in vertebrate eye development and disease
Eukaryotic DNA is organized as a nucleoprotein polymer termed chromatin with nucleosomes serving as its repetitive architectural units. Cellular differentiation is a dynamic process driven byExpand
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Transient loss of alphaB-crystallin: an early cellular response to mechanical stretch.
Human trabecular meshwork (HTM) is distended and stretched with increases in intraocular pressure. During this stretching, there is a rearrangement of actin filaments. The HTM cells express alphaExpand
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High-performance liquid chromatography-electrochemical detection of antioxidants in vertebrate lens: glutathione, tocopherol, and ascorbate.
The HPLC-EC method has good specificity for the analysis of glutathione, tocopherol, and ascorbate. The same HPLC system can be used for all three analysis with changes of mobile phase and theExpand
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The Transcription Factor Neural Retina Leucine Zipper (NRL) Controls Photoreceptor-specific Expression of Myocyte Enhancer Factor Mef2c from an Alternative Promoter*
Background: Mef2c gene expression is significantly diminished in the retinas of NRL (neural retina leucine zipper) knock-out mice. Results: NRL binding, RNA polymerase II association, and acetylationExpand
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