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SLC22A2 wt Allele

Known as: HOCT2, OCT2, Solute Carrier Family 22 (Organic Cation Transporter), Member 2 wt Allele 
Human SLC22A2 wild-type allele is located in the vicinity of 6q25.3 and is approximately 107 kb in length. This allele, which encodes solute carrier… 
National Institutes of Health

Related topics

Related topics

7 relations
Homo sapiensIonophore activityLigand BindingMolecular Transport

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
The conditional stimulation of rat organic cation transporter 2, but not its human ortholog, by mesoridazine: the possibility of the involvement of the high‐affinity binding site of the transporter…
To study the functional consequences of the human and rat forms of OCT2 in the presence of phenothiazines. 
2016
2016
Entecavir Interacts with Influx Transporters hOAT1, hCNT2, hCNT3, but Not with hOCT2: The Potential for Renal Transporter-Mediated Cytotoxicity and Drug–Drug Interactions
Entecavir (ETV) is one of the most potent agents for the treatment of the hepatitis B viral infection. The drug is principally… 
2013
2013
Interactions with selected drug renal transporters and transporter-mediated cytotoxicity in antiviral agents from the group of acyclic nucleoside phosphonates.
2012
2012
Interaction of antidepressant and antipsychotic drugs with the human organic cation transporters hOCT1, hOCT2 and hOCT3
Besides the three antidepressant-sensitive, Na+- and Cl−-dependent monoamine transporters, Na+-independent organic cation… 
Highly Cited
2011
Highly Cited
2011
OCT2 and MATE1 provide bidirectional agmatine transport.
Agmatine is a biogenic amine (l-arginine metabolite) of potential relevance to several central nervous system (CNS) conditions… 
Highly Cited
2008
Highly Cited
2008
Effect of Human Renal Cationic Transporter Inhibition on the Pharmacokinetics of Varenicline, a New Therapy for Smoking Cessation: An In Vitro–In Vivo Study
Varenicline is predominantly eliminated unchanged in urine, and active tubular secretion partially contributes to its renal… 
Highly Cited
2006
Highly Cited
2006
Characterization of regulatory mechanisms and states of human organic cation transporter 2.
Polyspecific organic cation transporters (OCTs) have a large substrate binding pocket with different interaction domains. To… 
2006
2006
Interactions of fluoroquinolone antibacterials, DX-619 and levofloxacin, with creatinine transport by renal organic cation transporter hOCT2.
Interactions of DX-619, a novel fluoroquinolone antibacterial, and levofloxacin (LVFX) with the human renal organic cation… 
Highly Cited
2002
Highly Cited
2002
Interactions of Human Organic Anion Transporters and Human Organic Cation Transporters with Nonsteroidal Anti-Inflammatory Drugs
The purpose of this study was to elucidate the interactions of human organic anion transporters (hOATs) and human organic cation… 
2000
2000
Characterization of MPP+ secretion across human intestinal Caco‐2 cell monolayers: role of P‐glycoprotein and a novel Na+‐dependent organic cation transport mechanism
In the kidney, a number of transport proteins involved in the secretion of permanently charged organic cations have recently been… 
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