Interactions with selected drug renal transporters and transporter-mediated cytotoxicity in antiviral agents from the group of acyclic nucleoside phosphonates.

@article{Mandkov2013InteractionsWS,
  title={Interactions with selected drug renal transporters and transporter-mediated cytotoxicity in antiviral agents from the group of acyclic nucleoside phosphonates.},
  author={J. Mand{\'i}kov{\'a} and M. Volkov{\'a} and P. P{\'a}vek and Michal {\vC}esnek and Z. Janeba and V. Kub{\'i}{\vc}ek and F. Trejtnar},
  journal={Toxicology},
  year={2013},
  volume={311 3},
  pages={
          135-46
        }
}
Members of acyclic nucleoside phosphonates (ANPs) possess antiviral and antiproliferative activities. However, several clinically important ANPs may cause renal injury, most likely due to their active accumulation in the renal tubular cells. The goal of this study was to investigate in vitro relationships between the affinity of several structurally related potent ANPs to selected human transporters and their cytotoxicity. SLC (solute carrier family) transporters (hOAT1, hOCT2, hCNT2, hCNT3… Expand
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