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Organic cation transporter 2 mediates cisplatin-induced oto- and nephrotoxicity and is a target for protective interventions.
The use of the effective antineoplastic agent cisplatin is limited by its serious side effects, such as oto- and nephrotoxicity. Ototoxicity is a problem of special importance in children, becauseExpand
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Organic cation transporters.
  • G. Ciarimboli
  • Medicine
  • Xenobiotica; the fate of foreign compounds in…
  • 2008
1. Organic cation transporters (OCTs) translocate endogenous (e.g. dopamine) and exogenous (e.g. drugs) substances of cationic nature and, therefore, play an important role in the detoxification ofExpand
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Cisplatin nephrotoxicity is critically mediated via the human organic cation transporter 2.
Cis-platin is an effective anti-neoplastic agent, but it is also highly nephrotoxic. Here, we clearly identify the human organic cation transporter 2 (hOCT2) as the critical transporter forExpand
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Proximal Tubular Secretion of Creatinine by Organic Cation Transporter OCT2 in Cancer Patients
Purpose: Knowledge of transporters responsible for the renal secretion of creatinine is key to a proper interpretation of serum creatinine and/or creatinine clearance as markers of renal function inExpand
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Individual PKC-phosphorylation sites in organic cation transporter 1 determine substrate selectivity and transport regulation.
To elucidate the molecular mechanisms underlying stimulation of rat organic cation transporter type 1 (rOCT1) by protein kinase C (PKC) activation, functional properties and regulation of rOCT1Expand
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Regulation of human organic cation transporter hOCT2 by PKA, PI3K, and calmodulin-dependent kinases.
Properties and regulation of the human organic cation (OC) transporter type 2 (hOCT2) expressed in HEK-293 cells were extensively characterized using the fluorescent OCExpand
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Membrane transporters as mediators of cisplatin side-effects.
The clinical use of the efficient chemotherapeutic drug cisplatin is limited by its specific severe organ toxicities such as nephro-, oto-, and also peripheral neurotoxicity. Membrane transportersExpand
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Regulation of the human organic cation transporter hOCT1
The human organic cation transporter type 1 (hOCT1) is an important transport system for small organic cations in the liver. Organic cation transporters are regulated by different signaling pathways,Expand
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A phosphotyrosine switch regulates organic cation transporters
Membrane transporters are key determinants of therapeutic outcomes. They regulate systemic and cellular drug levels influencing efficacy as well as toxicities. Here we report a uniqueExpand
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Identification of OAT1/OAT3 as Contributors to Cisplatin Toxicity
Cisplatin is among the most widely used anticancer drugs and known to cause a dose‐limiting nephrotoxicity, which is partially dependent on the renal uptake carrier OCT2. We here report a previouslyExpand
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