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SK&F 64139

Known as: SK&F-64139, SKF 64139 
National Institutes of Health

Papers overview

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1993
1993
Glucocorticoid induction of epinephrine synthesizing enzyme in rat skeletal muscle and insulin resistance.
Rat skeletal muscle contains two enzymes which can make epinephrine: phenylethanolamine N-methyltransferase (PNMT) and… 
1993
1993
Glucocorticoid hypertension and nonadrenal phenylethanolamine N-methyltransferase.
Several drugs that block epinephrine synthesis by inhibiting phenylethanolamine N-methyltransferase (PNMT) lower blood pressure… 
Highly Cited
1990
Highly Cited
1990
The adrenocorticotropin response to interleukin-1 beta instilled into the rat median eminence depends on the local release of catecholamines.
Interleukin-1 beta (IL-1 beta) is a potent ACTH secretagogue which activates the release of hypothalamic CRF but is unable to… 
1990
1990
Catecholamines mediate nicotine-induced adrenocorticotropin secretion via alpha-adrenergic receptors.
Previous studies determined that iv nicotine stimulates ACTH secretion by acting on sites accessible from the fourth ventricle… 
Highly Cited
1983
Highly Cited
1983
Effects of manipulating catecholamines on the incidence of the preovulatory surge of luteinizing hormone and ovulation in the rat: Evidence for a necessary involvement of hypothalamic adrenaline in…
1981
1981
Effect of adrenaline synthesis inhibition on brain noradrenaline neurons in locus coeruleus
1981
1981
Properties of 8,9-dichloro-2,3,4,5-tetrahydro-1H-2-benzazepine, an inhibitor of norepinephrine N-methyltransferase.
1980
1980
Adrenal influence on tyrosine hydroxylase activity in superior cervical ganglion
Highly Cited
1977
Highly Cited
1977
Effect of phenylethanolamine N-methyltransferase and dopamine-beta-hydroxylase inhibition on epinephrine levels in the brain.
Highly Cited
1976
Highly Cited
1976
Studies on adrenal phenylethanolamine N- methyltransferase (PNMT) with S K & F 64139, a selective inhibitor.
SK&F 64139 is a potent, reversible inhibitor of phenylethanolamine N-methyltransferase; its IC50 concentration in our standard… 
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