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SK&F 64139

Known as: SK&F-64139, SKF 64139 
National Institutes of Health

Papers overview

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Highly Cited
1990
Highly Cited
1990
The adrenocorticotropin response to interleukin-1 beta instilled into the rat median eminence depends on the local release of catecholamines.
Interleukin-1 beta (IL-1 beta) is a potent ACTH secretagogue which activates the release of hypothalamic CRF but is unable to… 
1990
1990
Catecholamines mediate nicotine-induced adrenocorticotropin secretion via alpha-adrenergic receptors.
Previous studies determined that iv nicotine stimulates ACTH secretion by acting on sites accessible from the fourth ventricle… 
1988
1988
Synthesis and evaluation of 3-substituted analogues of 1,2,3,4-tetrahydroisoquinoline as inhibitors of phenylethanolamine N-methyltransferase.
1,2,3,4-Tetrahydroisoquinoline (THIQ) and aryl-substituted derivatives of THIQ are potent inhibitors of the enzyme that catalyzes… 
1985
1985
Changes in concentrations and rate of decline of adrenaline in the medial preoptic area and mediobasal hypothalamus of acutely ovariectomized steroid-treated rats.
The presence of adrenaline within the central nervous system appears to be essential for the occurrence of an oestrogen… 
Highly Cited
1983
Highly Cited
1983
Effects of manipulating catecholamines on the incidence of the preovulatory surge of luteinizing hormone and ovulation in the rat: Evidence for a necessary involvement of hypothalamic adrenaline in…
1983
1983
Evidence for inhibition of sympathetic preganglionic neurons by bulbospinal epinephrine pathways
1981
1981
Effect of adrenaline synthesis inhibition on brain noradrenaline neurons in locus coeruleus
1981
1981
Properties of 8,9-dichloro-2,3,4,5-tetrahydro-1H-2-benzazepine, an inhibitor of norepinephrine N-methyltransferase.
Highly Cited
1977
Highly Cited
1977
Effect of phenylethanolamine N-methyltransferase and dopamine-beta-hydroxylase inhibition on epinephrine levels in the brain.
Highly Cited
1976
Highly Cited
1976
Studies on adrenal phenylethanolamine N- methyltransferase (PNMT) with S K & F 64139, a selective inhibitor.
SK&F 64139 is a potent, reversible inhibitor of phenylethanolamine N-methyltransferase; its IC50 concentration in our standard… 
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