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SIX3 gene

Known as: SINE OCULIS HOMEOBOX, DROSOPHILA, HOMOLOG OF, 3, SIX Homeobox 3 Gene, SIX homeobox 3 
This gene plays a role in retinal development.
National Institutes of Health

Related topics

Related topics

8 relations
Biologic DevelopmentCell Differentiation processHOLOPROSENCEPHALY 2 (disorder)Homo sapiens

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
The sea urchin animal pole domain is a Six3-dependent neurogenic patterning center
Two major signaling centers have been shown to control patterning of sea urchin embryos. Canonical Wnt signaling in vegetal… 
Highly Cited
2008
Highly Cited
2008
Regulation of a remote Shh forebrain enhancer by the Six3 homeoprotein
In humans, SHH haploinsufficiency results in holoprosencephaly (HPE), a defect in anterior midline formation. Despite the… 
Highly Cited
2004
Highly Cited
2004
Direct interaction of geminin and Six3 in eye development
Organogenesis in vertebrates requires the tight control of cell proliferation and differentiation. The homeobox-containing… 
Highly Cited
2003
Highly Cited
2003
Human genetics: You must remember this...
Highly Cited
2003
Highly Cited
2003
Six3 and Six6 activity is modulated by members of the groucho family
Six3 and Six6 are two genes required for the specification and proliferation of the eye field in vertebrate embryos, suggesting… 
Highly Cited
2002
Highly Cited
2002
Six3 inactivation reveals its essential role for the formation and patterning of the vertebrate eye.
The establishment of retinal identity and the subsequent patterning of the optic vesicle are the key steps in early vertebrate… 
Highly Cited
2002
Highly Cited
2002
Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors.
Recent findings suggest that Six3, a member of the evolutionarily conserved So/Six homeodomain family, plays an important role in… 
Highly Cited
1999
Highly Cited
1999
Six9 (Optx2), a new member of the Six gene family of transcription factors, is expressed at early stages of vertebrate ocular and pituitary development
Highly Cited
1998
Highly Cited
1998
Expression pattern of cSix3, a member of the Six/sine oculis family of transcription factors
Highly Cited
1998
Highly Cited
1998
Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification.
The homeobox gene Otx2 is a mouse cognate of the Drosophila orthodenticle gene, which is required for development of the brain… 
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