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Trapping of messenger RNA by Fragile X Mental Retardation protein into cytoplasmic granules induces translation repression.
- R. Mazroui, M. Huot, S. Tremblay, C. Filion, Y. Labelle, É. Khandjian
- BiologyHuman molecular genetics
- 15 November 2002
It is speculated that, in neurons, FMRP plays a role as a mRNA repressor in incompetent mRNP granules that have to be translocated from the cell body to distal locations such as dendritic spines and synaptosomes.
Proteomic investigation of phosphorylation sites in poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase.
It is shown that altered phosphorylation at specific sites can modify the dynamics of assembly and disassembly of PARP-1 at sites of DNA damage.
Fragile X Mental Retardation protein determinants required for its association with polyribosomal mRNPs.
- R. Mazroui, M. Huot, S. Tremblay, Nathalie Boilard, Y. Labelle, É. Khandjian
- BiologyHuman molecular genetics
- 1 December 2003
The results indicate that the KH RNA-binding domains and the Protein-Protein Interacting domain are essential for FMRP to associate with polyribosomal mRNPs, while the RGG box and the phosphorylated domains are dispensable.
Oncogenic conversion of a novel orphan nuclear receptor by chromosome translocation.
This work provides the second example of the oncogenic conversion of a nuclear receptor and the first example involving the orphan subfamily, and analysis of the disturbance induced by the EWS/TEc protein in the nuclear receptor network and their target genes may lead to new approaches for EMC treatment.
The RNA-binding protein fragile X-related 1 regulates somite formation in Xenopus laevis.
Fragile X-related 1 protein (FXR1P) is a member of a small family of RNA-binding proteins that includes the Fragile X mental retardation 1 protein (FMR1P) and the Fragile X-related 2 protein (FXR2P).…
Involvement of nuclear factor-kappaB in macrophage migration inhibitory factor gene transcription up-regulation induced by interleukin- 1 beta in ectopic endometrial cells.
The EWS/TEC fusion protein encoded by the t(9;22) chromosomal translocation in human chondrosarcomas is a highly potent transcriptional activator
Co-transfection experiments of COS cells and human chondrocytes indicate that whereas TEC moderately activates transcription from a NBRE-containing promoter, the corresponding EWS/TEC fusion protein is a highly potent transcriptional activator of the same promoter, being approximately 270-fold more active than the native receptor.
p21WAF1/CIP1 Upregulation through the Stress Granule-Associated Protein CUGBP1 Confers Resistance to Bortezomib-Mediated Apoptosis
It is found that depleting CUGBP1 in cancer cells prevents bortezomib-mediated p21 upregulation, which proposes that one key mechanism by which apoptosis is inhibited upon treatment with chemotherapeutic drugs might involve upregulation of the p21 protein through CU GBP1.
PARP-1-induced cell death through inhibition of the MEK/ERK pathway in MNNG-treated HeLa cells
Evidence is provided that PARP-1-induced cell death by MNNG exposure in HeLa cells is mediated in part through inhibition of the MEK/ERK signaling pathway and that inhibition of massive PAR synthesis by PJ34, which promotes sustained activation of ERK1/2, leads to cytoprotection.
The fragile x mental retardation syndrome 20 years after the FMR1 gene discovery: an expanding universe of knowledge.
- F. Rousseau, Y. Labelle, J. Bussières, C. Lindsay
- BiologyThe Clinical biochemist. Reviews
- 1 August 2011
Current knowledge on FXMR is summarised with an emphasis on the technical challenges of molecular diagnostics, on its prevalence and dynamics among populations, and on the potential of screening for FMR1 mutations.