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SIRT2 gene

Known as: SIRT2, SIR2, S. CEREVISIAE, HOMOLOG-LIKE 2, Sirtuin 2 Gene 
This gene plays a role in protein acetylation.
National Institutes of Health

Related topics

Related topics

6 relations
Cell divisionDeacetylationHydrolysisNAD-Dependent Deacetylase Sirtuin-2

Narrower (2)

SIRT2 wt AlleleSirtuin 2

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Expression profile of SIRT2 in human melanoma and implications for sirtuin-based chemotherapy
ABSTRACT Melanoma is cancer of melanin-containing melanocyte cells. This neoplasm is one of the most deadly forms of skin cancer… 
2016
2016
SIRT 2 inactivation reveals a subset of hyperacetylated perinuclear microtubules inaccessible to HDAC 6
Deacetylation of α-tubulin, lysine 40, is catalyzed by two enzymes, the NAD-dependent deacetylase SIRT2 and the NAD-independent… 
2014
2014
SIRT2 Expression Is Higher in Uveal Melanoma than In Ocular Melanocytes
Purpose: Sirtuins (SIRTs) are the family of proteins associated with the cell cycle and that correlate with cancer development… 
2012
2012
SIRT2 Protein Expression in Normal and Aged Rat Brain
Background: Studies on surtuin2 (SIRT2) proteins, particularly those focusing on the nervous system, have not been intensively… 
2011
2011
Mechanism-based affinity capture of sirtuins.
The ability to probe for catalytic activities of enzymes and to detect their abundance in complex biochemical contexts has… 
2010
2010
Reply to Valenza and Cattaneo: SIRT2-mediated neuroprotection and cholesterol dyshomeostasis in Huntington’s disease
Our study provides evidence that sirtuin 2 (SIRT2) inhibition is a potential therapeutic avenue in Huntington’s disease (HD) and… 
2009
2009
9-Fluorenylmethoxycarbonyl-labeled peptides as substrates in a capillary electrophoresis-based assay for sirtuin enzymes.
2008
2008
Design and Synthesis of Silent Information Regulator Human Type 2 (SIRT2) Inhibitors
Silent information regulator human type 2 (SIRT2) enzyme belongs to the class III histone deacetylases (HDAC). It is one of the… 
2006
2006
N,N'-Bisbenzylidenebenzene-1,4-diamines and N,N'-Bisbenzylidenenaphthalene-1,4-diamines as Sirtuin Type 2 (SIRT2) Inhibitors.
A series of N,N'-bisbenzylidenebenzene-1,4-diamine and N,N'-bisbenzylidenenaphthalene-1,4-diamine derivatives were synthesized as… 
2006
2006
Expression and sequence of canine SIRT2 and p53 genes in canine mammary tumour cells - effects on downstream targets Wip1 and p21/Cip1.
We have characterized gene dysfunction in a cellular model of spontaneous canine mammary cancer by investigating specific gene… 
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