SIRT2 gene

Known as: SIRT2, SIR2, S. CEREVISIAE, HOMOLOG-LIKE 2, Sirtuin 2 Gene 
This gene plays a role in protein acetylation.
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Although initially viewed as unregulated, increasing evidence suggests that cellular necrosis often proceeds through a specific… (More)
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Highly Cited
2012
Highly Cited
2012
Dietary obesity is a major factor in the development of type 2 diabetes and is associated with intra-adipose tissue hypoxia and… (More)
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Highly Cited
2011
Highly Cited
2011
Members of sirtuin family regulate multiple critical biological processes, yet their role in carcinogenesis remains controversial… (More)
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Highly Cited
2010
Highly Cited
2010
NF-κB regulates the expression of a large number of target genes involved in the immune and inflammatory response, apoptosis… (More)
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Highly Cited
2010
Highly Cited
2010
Huntington's disease (HD), an incurable neurodegenerative disorder, has a complex pathogenesis including protein aggregation and… (More)
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Highly Cited
2010
Highly Cited
2010
SIRT proteins play an important role in the survival and drug resistance of tumor cells, especially during chemotherapy. In this… (More)
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Highly Cited
2007
Highly Cited
2007
The human NAD+-dependent protein deacetylase SIRT2 resides predominantly in the cytoplasm where it functions as a tubulin… (More)
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Highly Cited
2007
Highly Cited
2007
We previously identified SIRT2, an nicotinamide adenine dinucleotide (NAD)-dependent tubulin deacetylase, as a protein… (More)
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Highly Cited
2003
Highly Cited
2003
Studies of yeast have shown that the SIR2 gene family is involved in chromatin structure, transcriptional silencing, DNA repair… (More)
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Highly Cited
2001
Highly Cited
2001
Sir2 is an NAD-dependent histone deacetylase that mediates transcriptional silencing at mating-type loci, telomeres and ribosomal… (More)
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