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SIRT2 gene

Known as: SIRT2, SIR2, S. CEREVISIAE, HOMOLOG-LIKE 2, Sirtuin 2 Gene 
This gene plays a role in protein acetylation.
National Institutes of Health

Related topics

Related topics

6 relations
Cell divisionDeacetylationHydrolysisNAD-Dependent Deacetylase Sirtuin-2

Narrower (2)

SIRT2 wt AlleleSirtuin 2

Papers overview

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2014
2014
Decreased SIRT2 activity leads to altered microtubule dynamics in oxidatively-stressed neuronal cells: Implications for Parkinson's disease
2014
2014
Deacetylation of phosphoglycerate mutase in its distinct central region by SIRT2 down‐regulates its enzymatic activity
Substantially high rate of glycolysis, known as the Warburg effect, is a well‐known feature of cancers, and emerging evidence… 
2013
2013
The SIRT2 polymorphism rs10410544 and risk of Alzheimer’s disease in two Caucasian case–control cohorts
2013
2013
Sirtuin 2 (SIRT2) enhances 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigrostriatal damage via deacetylating forkhead box O3a (Foxo3a) and activating Bim protein.
Abstract Sirtuins are NAD-dependent protein deacetylases that were shown to have beneficial effects against age-related diseases… 
Highly Cited
2010
Highly Cited
2010
Role of TPPP/p25 on α-synuclein-mediated oligodendroglial degeneration and the protective effect of SIRT2 inhibition in a cellular model of multiple system atrophy
Highly Cited
2009
Highly Cited
2009
SIRT2 downregulation confers resistance to microtubule inhibitors by prolonging chronic mitotic arrest
We previously identified SIRT2, a deacetylase for tubulin and histone H4, as a protein down-regulated in gliomas, and reported… 
2008
2008
SIRT2, tubulin deacetylation, and oligodendroglia differentiation.
The mammalian silent information regulator 2 (SIRT2) is an NAD-dependent histone deacetylase with known roles in the regulation… 
Highly Cited
2007
Highly Cited
2007
Linking SIRT2 to Parkinson's disease.
A recent study has identified selective inhibitors of the human silent information regulator 2 NAD (+)-dependent protein… 
2006
2006
N,N'-Bisbenzylidenebenzene-1,4-diamines and N,N'-Bisbenzylidenenaphthalene-1,4-diamines as Sirtuin Type 2 (SIRT2) Inhibitors.
A series of N,N'-bisbenzylidenebenzene-1,4-diamine and N,N'-bisbenzylidenenaphthalene-1,4-diamine derivatives were synthesized as… 
Highly Cited
1999
Highly Cited
1999
Characterization of a human gene with sequence homology to Saccharomyces cerevisiae SIR2.
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