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Sirtuin 2

Known as: Silent Mating Type Information Regulation 2 Homolog 2, Sirtuin 2 [Chemical/Ingredient] 
A sirtuin family member found primarily in the CYTOPLASM. It is a multifunctional enzyme that contains a NAD-dependent deacetylase activity that is… 
National Institutes of Health

Related topics

Related topics

10 relations

Narrower (2)

HST2 protein, S cerevisiaeSIR2 protein, S cerevisiae
In BloodProcess of secretionantagonists & inhibitorsaspects of radiation effects

Broader (1)

SIRT2 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2018
Highly Cited
2018
SIRT2 Inhibition Confers Neuroprotection by Downregulation of FOXO3a and MAPK Signaling Pathways in Ischemic Stroke
Sirtuin 2 (SIRT2) is a family member of nicotinamide adenine dinucleotide (NAD+)-dependent deacetylases which appears to have… 
2018
2018
Novel small molecule SIRT2 inhibitors induce cell death in leukemic cell lines
Sirtuin 2 (SIRT2) is a member of the sirtuin family, nicotinamide adenine dinucleotide+-dependent deacylases, which participates… 
2017
2017
Downregulation of NAD-Dependent Deacetylase SIRT2 Protects Mouse Brain Against Ischemic Stroke
Sirtuin 2 (SIRT2) is a member of NAD+-dependent protein deacetylases involved in a wide range of pathophysiological processes… 
Highly Cited
2016
Highly Cited
2016
Sirtuin 2 Inhibition Improves Cognitive Performance and Acts on Amyloid-β Protein Precursor Processing in Two Alzheimer's Disease Mouse Models.
The neuropathological hallmarks of Alzheimer's disease (AD) are extracellular plaques built up by the accumulation of the amyloid… 
Highly Cited
2016
Highly Cited
2016
SIRT2 inhibition exacerbates neuroinflammation and blood–brain barrier disruption in experimental traumatic brain injury by enhancing NF‐κB p65 acetylation and activation
Sirtuin 2 (SIRT2) is a member of the sirtuin family of NAD+‐dependent protein deacetylases. In recent years, SIRT2 inhibition has… 
2016
2016
Downregulation of NAD-Dependent Deacetylase SIRT2 Protects Mouse Brain Against Ischemic Stroke
Sirtuin 2 (SIRT2) is a member of NAD+-dependent protein deacetylases involved in a wide range of pathophysiological processes… 
2014
2014
SIRT2 mediates oxidative stress-induced apoptosis of differentiated PC12 cells
Sirtuin 2 (SIRT2) is a member of the sirtuin family. Previous studies have suggested that SIRT2 mediates the cell death in models… 
2014
2014
SIRT2 plays a key role in both cell cycle regulation and cell survival of BV2 microglia.
Sirtuin 2 (SIRT2) is a member of sirtuin protein family. Previous studies have suggested that SIRT2 plays differential roles in… 
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