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SIRT1 gene

Known as: SIR2L1, SIR2, S. CEREVISIAE, HOMOLOG-LIKE 1, SIRT1 
This gene may be involved in the regulation of protein acetylation.
National Institutes of Health

Related topics

Related topics

8 relations
DNA RepairDNA ReplicationEpigenetic SilencingHydrolysis

Narrower (2)

SIRT1 wt AlleleSirtuin 1

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Calorie restriction attenuates cerebral ischemic injury via increasing SIRT1 synthesis in the rat
2015
2015
Over-expression of Sirt1 contributes to chemoresistance and indicates poor prognosis in serous epithelial ovarian cancer (EOC)
Abstract Ovarian cancer is the most lethal malignancy in female patients, and chemoresistance is the major contribution to low… 
Highly Cited
2012
Highly Cited
2012
SIRT1 attenuates palmitate-induced endoplasmic reticulum stress and insulin resistance in HepG2 cells via induction of oxygen-regulated protein 150.
Review
2011
Review
2011
Sirtuin 1 in malignant transformation: friend or foe?
Highly Cited
2011
Highly Cited
2011
Interference between PARPs and SIRT1: a novel approach to healthy ageing?
Poly(ADP-ribosyl) polymerases (PARPs) have traditionally been linked to chromosome maintenance and DNA repair. Recent findings… 
Review
2010
Review
2010
Sirtuin activators: designing molecules to extend life span.
Highly Cited
2009
Highly Cited
2009
Distinct HIC1-SIRT1-p53 loop deregulation in lung squamous carcinoma and adenocarcinoma patients.
A HIC1-SIRT1-p53 circular loop in which hypermethylation in cancer 1 (HIC1) represses the transcription of SIRT1 that… 
Highly Cited
2008
Highly Cited
2008
Enhanced tolerance against early and late apoptotic oxidative stress in mammalian neurons through nicotinamidase and sirtuin mediated pathways.
Focus upon therapeutic strategies that intersect between pathways that govern cellular metabolism and cellular survival may offer… 
Review
2007
Review
2007
A Functional Link Between SIRT1 Deacetylase and NBS1 in DNA Damage Response
In mammalian cells, DNA is often subjected to stresses such as ionizing radiation (IR) and ultraviolet light that can induce DNA… 
2007
2007
Expression and localization of Werner syndrome protein is modulated by SIRT1 and PML
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