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SIRT1 gene

Known as: SIR2L1, SIR2, S. CEREVISIAE, HOMOLOG-LIKE 1, SIRT1 
This gene may be involved in the regulation of protein acetylation.
National Institutes of Health

Related topics

Related topics

8 relations
DNA RepairDNA ReplicationEpigenetic SilencingHydrolysis

Narrower (2)

SIRT1 wt AlleleSirtuin 1

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Regulation of FOXOs and p53 by SIRT1 Modulators under Oxidative Stress
Excessive reactive oxygen species (ROS) induce apoptosis and are associated with various diseases and with aging. SIRT1 (sirtuin… 
Highly Cited
2012
Highly Cited
2012
Activation of p53 by SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with imatinib.
Highly Cited
2011
Highly Cited
2011
Sirt1 acts in association with PPARα to protect the heart from hypertrophy, metabolic dysregulation, and inflammation.
AIMS A complex set of metabolic and inflammatory processes are involved in the development of cardiac hypertrophy. Accumulating… 
Highly Cited
2010
Highly Cited
2010
SIRT1 Negatively Regulates the Mammalian Target of Rapamycin
The IGF/mTOR pathway, which is modulated by nutrients, growth factors, energy status and cellular stress regulates aging in… 
Highly Cited
2009
Highly Cited
2009
Resveratrol induces mitochondrial biogenesis in endothelial cells
Pathways that regulate mitochondrial biogenesis are potential therapeutic targets for the amelioration of endothelial dysfunction… 
Highly Cited
2009
Highly Cited
2009
Enzymes in the NAD+ Salvage Pathway Regulate SIRT1 Activity at Target Gene Promoters*
In mammals, nic o tin a mide phosphoribosyltransferase (NAMPT) and nic o tin a mide mononucleotide ad en y lyltransferase 1… 
Highly Cited
2008
Highly Cited
2008
Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt.
Highly Cited
2008
Highly Cited
2008
Double Strand Breaks Can Initiate Gene Silencing and SIRT1-Dependent Onset of DNA Methylation in an Exogenous Promoter CpG Island
Chronic exposure to inducers of DNA base oxidation and single and double strand breaks contribute to tumorigenesis. In addition… 
Highly Cited
2006
Highly Cited
2006
Hormonal Control of Androgen Receptor Function through SIRT1
ABSTRACT The NAD-dependent histone deacetylase Sir2 plays a key role in connecting cellular metabolism with gene silencing and… 
Highly Cited
2005
Highly Cited
2005
SIRT1 Deacetylation and Repression of p300 Involves Lysine Residues 1020/1024 within the Cell Cycle Regulatory Domain 1*
The SIR2 family of nicotinamide adenosine dinucleotide (NAD)-dependent deacetylases modulates diverse biological functions in… 
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