SIRT1 gene

Known as: SIR2L1, SIR2, S. CEREVISIAE, HOMOLOG-LIKE 1, SIRT1 
This gene may be involved in the regulation of protein acetylation.
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Resveratrol induces mitochondrial biogenesis and protects against metabolic decline, but whether SIRT1 mediates these benefits is… (More)
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Highly Cited
2009
Highly Cited
2009
AMP-activated protein kinase (AMPK) is a metabolic fuel gauge conserved along the evolutionary scale in eukaryotes that senses… (More)
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Highly Cited
2008
Highly Cited
2008
The mammalian circadian timing system is composed of a central pacemaker in the suprachiasmatic nucleus of the brain that… (More)
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Highly Cited
2008
Highly Cited
2008
The identification of new pharmacological approaches to effectively prevent, treat, and cure the metabolic syndrome is of crucial… (More)
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Highly Cited
2007
Highly Cited
2007
A progressive loss of neurons with age underlies a variety of debilitating neurological disorders, including Alzheimer's disease… (More)
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Highly Cited
2006
Highly Cited
2006
Diminished mitochondrial oxidative phosphorylation and aerobic capacity are associated with reduced longevity. We tested whether… (More)
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Highly Cited
2005
Highly Cited
2005
Homeostatic mechanisms in mammals respond to hormones and nutrients to maintain blood glucose levels within a narrow range… (More)
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Highly Cited
2004
Highly Cited
2004
Calorie restriction extends lifespan in organisms ranging from yeast to mammals. In yeast, the SIR2 gene mediates the life… (More)
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Highly Cited
2004
Highly Cited
2004
NF-kappaB is responsible for upregulating gene products that control cell survival. In this study, we demonstrate that SIRT1, a… (More)
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Highly Cited
2004
Highly Cited
2004
The Sir2 deacetylase modulates organismal life-span in various species. However, the molecular mechanisms by which Sir2 increases… (More)
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