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Epigenetic Silencing

This process is initiated by the formation of heterochromatin which ultimately leads to transcriptional inactivation or silencing. Once formed… 
National Institutes of Health

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8 relations
HIST1H3B geneHIST1H3B wt AlleleHistone H3.1Hypermethylation

Papers overview

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Highly Cited
2014
Highly Cited
2014
Epigenetic silencing of CHD5, a novel tumor‐suppressor gene, occurs in early colorectal cancer stages
Chromodomain helicase DNA binding protein 5 (CHD5) is a family member of chromatin remodeling factors. The epigenetic silencing… 
2012
2012
WT1 CpG islands methylation in human lung cancer: a pilot study.
Highly Cited
2011
Highly Cited
2011
Long-Range Epigenetic Silencing Associates with Deregulation of Ikaros Targets in Colorectal Cancer Cells
Transcription factors are common targets of epigenetic inactivation in human cancer. Promoter hypermethylation and subsequent… 
2011
2011
Transcription factor AP4 modulates reversible and epigenetic silencing of the Cd4 gene
CD4 coreceptor expression is negatively regulated through activity of the Cd4 silencer in CD4–CD8– double-negative (DN… 
2010
2010
Aberrant Epigenetic Silencing of Tumor Suppressor Genes Is Reversed by Direct Reprogramming
Direct reprogramming procedures reset the epigenetic memory of cells and convert differentiated somatic cells into pluripotent… 
2010
2010
Hepatocyte nuclear factor (HNF)-4α-driven epigenetic silencing of the human PED gene
Aims/hypothesisOverexpression of PED (also known as PEA15) determines insulin resistance and impaired insulin secretion and may… 
Highly Cited
2009
Highly Cited
2009
Phospholipase C delta 1 is a novel 3p22.3 tumor suppressor involved in cytoskeleton organization, with its epigenetic silencing correlated with high-stage gastric cancer
Located at the important tumor suppressor locus, 3p22, PLCD1 encodes an enzyme that mediates regulatory signaling of energy… 
2006
2006
Reversal of p53 epigenetic silencing in multiple myeloma permits apoptosis by a p53 activator
Inactivation of the p53 pathway is a common feature of neoplasia. Dysregulation of the p53 pathway has been shown to involve… 
2006
2006
Epigenetic silencing contributes to frequent loss of the fragile histidine triad tumour suppressor in basal cell carcinomas
Background  Extensive exposure to ultraviolet radiation is associated with genetic alterations in basal cell carcinomas (BCCs… 
Highly Cited
2001
Highly Cited
2001
Epigenetic silencing of PEG3 gene expression in human glioma cell lines *
Genomic imprinting, the phenomenon in which alleles of genes are expressed differentially depending on their parental origins… 
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