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High incidence of microsatellite instability in colorectal cancer from African Americans.
- H. Ashktorab, D. Smoot, +9 authors F. Giardiello
- Biology, Medicine
- Clinical cancer research : an official journal of…
- 1 March 2003
PURPOSE Colorectal carcinoma (CRC) is the second most common cause of cancer death in the United States, and the rate of CRC is nearly 1.5 times higher in African-Americans (AA) than in Caucasians.… Expand
Distinct Genetic Alterations in Colorectal Cancer
- H. Ashktorab, A. Schäffer, M. Daremipouran, D. Smoot, E. Lee, H. Brim
- Biology, Medicine
- PloS one
- 26 January 2010
Background Colon cancer (CRC) development often includes chromosomal instability (CIN) leading to amplifications and deletions of large DNA segments. Epidemiological, clinical, and cytogenetic… Expand
CD44-SLC1A2 Gene Fusions in Gastric Cancer
One partner of a fusion gene found in gastric cancer, CD44-SLC1A2, may contribute to the tumor’s abnormal metabolism. Bad Drivers Steer Scientists Toward New Drug Targets It’s ironic, but cancer… Expand
Epigenetic inactivation of endothelin‐2 and endothelin‐3 in colon cancer
- R. Wang, Christiane V. Löhr, +7 authors Roderick H. Dashwood
- Medicine, Biology
- International journal of cancer
- 1 March 2013
Endothelin‐1 (ET‐1) and its receptors are overexpressed in human cancers, but much less is known about the roles of ET‐2 and ET‐3 in cancer etiology. We sought to examine human and rat colon tumors… Expand
Influence of Helicobacter pylori on reactive oxygen-induced gastric epithelial cell injury.
Risk factors for gastric cancer are receiving renewed attention in light of the recent positive association of Helicobacter pylori infection with gastric cancer. The effect of H.pylori on the balance… Expand
Distinct BRAF (V600E) and KRAS Mutations in High Microsatellite Instability Sporadic Colorectal Cancer in African Americans
Purpose: Colorectal cancer develops through genetic, epigenetic, and environmental events that result in uncontrolled cell proliferation. Colorectal cancer incidence and mortality is higher in… Expand
Helicobacter pylori Endemic and Gastric Disease
- F. Siavoshi, R. Malekzadeh, M. Daneshmand, H. Ashktorab
- Digestive Diseases and Sciences
- 1 November 2005
H. pylori infection of the stomach is widespread among human populations including Iranians and is considered to play a major role in the pathogenesis of gastric diseases such as peptic ulcer,… Expand
Promoter methylation regulates Helicobacter pylori-stimulated cyclooxygenase-2 expression in gastric epithelial cells.
Cyclooxygenase (COX)-2, the inducible form of the rate-limiting enzyme for prostaglandin synthesis, is up-regulated in gastrointestinal cancers and is a key mediator of epithelial cell growth.… Expand
Cathepsin S mediates gastric cancer cell migration and invasion via a putative network of metastasis-associated proteins.
Cancer progression is governed by multifaceted interactions of cancer cells with their microenvironment and one of these ways is through secreted compounds. Substances released by gastric cancer… Expand
Distinct High-Profile Methylated Genes in Colorectal Cancer
Background Mutations and promoters' methylation of a set of candidate cancer genes (CAN genes) are associated with progression of colorectal cancer (CRC). We hypothesized that these genes' promoters… Expand