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Hypermethylation

Hypermethylation appears to be a controlled, epigenetic, heritable, and aberrant DNA methylation reaction on gene promoter regions and CpG islands… Expand
National Institutes of Health

Related topics

Related topics

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Epigenetic Silencing

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
Brain changes in a maternal immune activation model of neurodevelopmental brain disorders
HighlightsMaternal Immune activation (MIA) is associated with increased risk for various neurodevelopmental and neurodegenerative… Expand
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Review
2018
Review
2018
Outlooks on Epstein-Barr virus associated gastric cancer.
Epstein-Barr virus associated gastric cancer (EBVaGC) comprises approximately 10% of gastric carcinomas. Multiple factors… Expand
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Review
2018
Review
2018
Fusobacterium and Colorectal Cancer
Colorectal cancer (CRC) is the third most common cancer worldwide and its pathogenesis has been extensively explored over the… Expand
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Highly Cited
2010
Highly Cited
2010
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation.
Cancer-associated IDH mutations are characterized by neomorphic enzyme activity and resultant 2-hydroxyglutarate (2HG) production… Expand
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Highly Cited
2009
Highly Cited
2009
The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores
For the past 25 years, it has been known that alterations in DNA methylation (DNAm) occur in cancer, including hypomethylation of… Expand
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Review
2002
Review
2002
CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future
We have come a long way since the first reports of the existence of aberrant DNA methylation in human cancer. Hypermethylation of… Expand
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Highly Cited
2001
Highly Cited
2001
A gene hypermethylation profile of human cancer.
We are in an era where the potential exists for deriving comprehensive profiles of DNA alterations characterizing each form of… Expand
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Review
2000
Review
2000
DNA hypermethylation in tumorigenesis: epigenetics joins genetics.
Recently, the concept that epigenetic, as well as genetic, events might be central to the evolution of human cancer is re… Expand
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Highly Cited
2000
Highly Cited
2000
Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors.
BACKGROUND Inherited mutations in the BRCA1 gene may be responsible for almost half of inherited breast carcinomas. However… Expand
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Highly Cited
1998
Highly Cited
1998
Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma.
Inactivation of the genes involved in DNA mismatch repair is associated with microsatellite instability (MSI) in colorectal… Expand
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