Hypermethylation

Hypermethylation appears to be a controlled, epigenetic, heritable, and aberrant DNA methylation reaction on gene promoter regions and CpG islands… (More)
National Institutes of Health

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Epigenetic Silencing

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Highly Cited
2010
Highly Cited
2010
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation.
Cancer-associated IDH mutations are characterized by neomorphic enzyme activity and resultant 2-hydroxyglutarate (2HG) production… (More)
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Highly Cited
2010
Highly Cited
2010
Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains.
There is a growing realization that some aging-associated phenotypes/diseases have an epigenetic basis. Here, we report the first… (More)
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Highly Cited
2009
Highly Cited
2009
The human colon cancer methylome shows similar hypo-and hypermethylation at conserved tissue-specific CpG island shores
For the past 25 years, it has been known that alterations in DNA methylation (DNAm) occur in cancer, including hypomethylation of… (More)
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Highly Cited
2007
Highly Cited
2007
A stem cell–like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing
Adult cancers may derive from stem or early progenitor cells. Epigenetic modulation of gene expression is essential for normal… (More)
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Review
2002
Review
2002
CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future
We have come a long way since the first reports of the existence of aberrant DNA methylation in human cancer. Hypermethylation of… (More)
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Highly Cited
2002
Highly Cited
2002
Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor.
DNA methylation of tumor suppressor genes is a frequent mechanism of transcriptional silencing in cancer. The molecular… (More)
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Highly Cited
2000
Highly Cited
2000
Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors.
BACKGROUND Inherited mutations in the BRCA1 gene may be responsible for almost half of inherited breast carcinomas. However… (More)
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Review
2000
Review
2000
DNA hypermethylation in tumorigenesis: epigenetics joins genetics.
Recently, the concept that epigenetic, as well as genetic, events might be central to the evolution of human cancer is re… (More)
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Highly Cited
1999
Highly Cited
1999
Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients.
Recent evidence suggests that tumor cells may release DNA into the circulation, which is enriched in the serum and plasma… (More)
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Highly Cited
1998
Highly Cited
1998
Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma.
Inactivation of the genes involved in DNA mismatch repair is associated with microsatellite instability (MSI) in colorectal… (More)
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