Hypermethylation

Hypermethylation appears to be a controlled, epigenetic, heritable, and aberrant DNA methylation reaction on gene promoter regions and CpG islands… (More)
National Institutes of Health

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Highly Cited
2010
Highly Cited
2010
Cancer-associated IDH mutations are characterized by neomorphic enzyme activity and resultant 2-hydroxyglutarate (2HG) production… (More)
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Highly Cited
2010
Highly Cited
2010
There is a growing realization that some aging-associated phenotypes/diseases have an epigenetic basis. Here, we report the first… (More)
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Highly Cited
2009
Highly Cited
2009
For the past 25 years, it has been known that alterations in DNA methylation (DNAm) occur in cancer, including hypomethylation of… (More)
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Highly Cited
2007
Highly Cited
2007
Adult cancers may derive from stem or early progenitor cells. Epigenetic modulation of gene expression is essential for normal… (More)
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Review
2002
Review
2002
We have come a long way since the first reports of the existence of aberrant DNA methylation in human cancer. Hypermethylation of… (More)
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Highly Cited
2002
Highly Cited
2002
DNA methylation of tumor suppressor genes is a frequent mechanism of transcriptional silencing in cancer. The molecular… (More)
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Highly Cited
2000
Highly Cited
2000
BACKGROUND Inherited mutations in the BRCA1 gene may be responsible for almost half of inherited breast carcinomas. However… (More)
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Review
2000
Review
2000
Recently, the concept that epigenetic, as well as genetic, events might be central to the evolution of human cancer is re… (More)
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Highly Cited
1999
Highly Cited
1999
Recent evidence suggests that tumor cells may release DNA into the circulation, which is enriched in the serum and plasma… (More)
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Highly Cited
1998
Highly Cited
1998
Inactivation of the genes involved in DNA mismatch repair is associated with microsatellite instability (MSI) in colorectal… (More)
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