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Hypermethylation

Hypermethylation appears to be a controlled, epigenetic, heritable, and aberrant DNA methylation reaction on gene promoter regions and CpG islands… 
National Institutes of Health

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Related topics

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Epigenetic Silencing

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Re: Epigenetic disruption of the PIWI pathway in human spermatogenic disorders.
Highly Cited
2003
Highly Cited
2003
Promoter hypermethylation of multiple genes in astrocytic gliomas.
Promoter hypermethylation represents a primary mechanism in the inactivation of tumor suppressor genes during tumorigenesis. To… 
Review
2003
Review
2003
Hepatocyte growth factor activator inhibitor 2/placental bikunin (HAI-2/PB) gene is frequently hypermethylated in human hepatocellular carcinoma.
Review
2002
Review
2002
DNA methylation changes in leukaemia.
Highly Cited
2001
Highly Cited
2001
Promoter hypermethylation of MGMT is associated with protein loss in gastric carcinoma
Aberrant methylation of CpG islands within promoter regions is associated with transcriptional inactivation of various tumor… 
Highly Cited
2000
Highly Cited
2000
p16 is a major inactivation target in hepatocellular carcinoma
The p16INK4A gene encodes 2 cell cycle regulator proteins, p16 and p14ARF, by alternative splicing. This genetic locus also… 
Highly Cited
2000
Highly Cited
2000
Correlation of p16 Hypermethylation with p16 Protein Loss in Sporadic Gastric Carcinomas
Hypermethylation of p16 has been detected frequently in a variety of cancer cells and is known to repress the level of p16… 
Review
2000
Review
2000
Genetic and epigenetic alterations in carcinogenesis.
Highly Cited
1998
Highly Cited
1998
Genetic and epigenetic alterations of the cyclin‐dependent kinase inhibitors p15INK4b and p16INK4a in human thyroid carcinoma cell lines and primary thyroid carcinomas
D‐type cyclins, in association with the cyclin‐dependent kinases CDK4 and CDK6, promote progression through the G1 phase of the… 
Highly Cited
1965
Highly Cited
1965
Synthesis and transmethylation of DNA in polyoma-infected cultures.
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