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SHC1 wt Allele

Known as: SHC, SHC (Src Homology 2 Domain Containing) Transforming Protein 1 wt Allele, SHCA 
Human SHC1 wild-type allele is located in the vicinity of 1q21 and is approximately 12 kb in length. This allele, which encodes SHC-transforming… 
National Institutes of Health

Related topics

Related topics

31 relations
1q21Angiogenesis PathwayAngiotensin II Signaling PathwayB Cell Receptor Signaling Pathway

Broader (1)

SHC1 gene

Papers overview

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Highly Cited
2008
Highly Cited
2008
Signaling through ShcA Is Required for Transforming Growth Factor β- and Neu/ErbB-2-Induced Breast Cancer Cell Motility and Invasion
ABSTRACT Cooperation between the Neu/ErbB-2 and transforming growth factor β (TGF-β) signaling pathways enhances the invasive and… 
Highly Cited
2004
Highly Cited
2004
The Shc adaptor protein is critical for VEGF induction by Met/HGF and ErbB2 receptors and for early onset of tumor angiogenesis.
The etiology and progression of a variety of human malignancies are linked to the deregulation of receptor tyrosine kinases (RTKs… 
Highly Cited
2000
Highly Cited
2000
NF-κB Signaling Promotes Both Cell Survival and Neurite Process Formation in Nerve Growth Factor-Stimulated PC12 Cells
Nerve growth factor binds to the TrkA and p75NTR (p75) and generates signals leading to neuronal cell survival, differentiation… 
Highly Cited
1999
Highly Cited
1999
Protein interactions of Src homology 2 (SH2) domain-containing inositol phosphatase (SHIP): association with Shc displaces SHIP from FcgammaRIIb in B cells.
Our recent studies revealed that the inositol phosphatase Src homology 2 (SH2) domain-containing inositol phosphatase (SHIP) is… 
Highly Cited
1999
Highly Cited
1999
Shc Regulates Epidermal Growth Factor-induced Activation of the JNK Signaling Pathway*
Two adaptor molecules, Grb2 and Shc, have been implicated in the extracellular signal-regulated kinase (ERK) activation by… 
Highly Cited
1999
Highly Cited
1999
SHC and SHIP phosphorylation and interaction in response to activation of the FLT3 receptor
The FLT3 receptor tyrosine kinase and its ligand, FL, regulate the development of hematopoietic stem cells and early B lymphoid… 
Highly Cited
1998
Highly Cited
1998
A flavonoid antioxidant, silymarin, inhibits activation of erbB1 signaling and induces cyclin-dependent kinase inhibitors, G1 arrest, and anticarcinogenic effects in human prostate carcinoma DU145…
Prostate cancer (PCA) is the most common nonskin malignancy and the second leading cause of cancer deaths in United States males… 
Highly Cited
1996
Highly Cited
1996
Activation-induced Association of a 145-kDa Tyrosine-phosphorylated Protein with Shc and Syk in B Lymphocytes and Macrophages (*)
Engagement of many cell surface receptors results in tyrosine phosphorylation of an overlapping set of protein substrates. Some… 
Highly Cited
1995
Highly Cited
1995
Distinct regions of c-Mpl cytoplasmic domain are coupled to the JAK-STAT signal transduction pathway and Shc phosphorylation.
c-Mpl, a member of the hematopoietic cytokine receptor family, is the receptor for thrombopoietin. To investigate signal… 
Highly Cited
1995
Highly Cited
1995
Erythropoietin-induced recruitment of Shc via a receptor phosphotyrosine-independent, Jak2-associated pathway
Based on the recently implicated role of Shc as a signaling effector for type I cytokine receptors, factors which mediate the… 
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