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SH2D1A wt Allele

Known as: SH2 Domain Protein 1A, Duncan's Disease (Lymphoproliferative Syndrome) wt Allele, SAP, LYP 
Human SH2D1A wild-type allele is located within Xq25-q26 and is approximately 27 kb in length. This allele, which encodes SH2 domain protein 1A… Expand
National Institutes of Health

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Highly Cited
2012
Highly Cited
2012
Humans and mice deficient in the adaptor protein SAP (Sh2d1a) have a major defect in humoral immunity, resulting from a lack of T… Expand
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Highly Cited
2012
Highly Cited
2012
X-linked lymphoproliferative syndrome, characterized by fatal responses to Epstein-Barr virus infection, is caused by mutations… Expand
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Highly Cited
2005
Highly Cited
2005
SAP is an adaptor protein expressed in T cells and natural killer cells. It plays a critical role in immunity, as it is mutated… Expand
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Highly Cited
2004
Highly Cited
2004
XLP is caused by mutations affecting SAP, an adaptor that recruits Fyn to SLAM family receptors. SAP-deficient mice recapitulate… Expand
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Highly Cited
2004
Highly Cited
2004
SAP is an adaptor mutated in X-linked lymphoproliferative disease. It plays a critical role in T helper 2 (T(H)2) cytokine… Expand
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Highly Cited
2003
Highly Cited
2003
Long-lived plasma cells and memory B cells are the primary cellular components of long-term humoral immunity and as such are… Expand
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Highly Cited
2003
Highly Cited
2003
SAP (or SH2D1A), an adaptor-like molecule expressed in immune cells, is composed almost exclusively of a Src homology 2 (SH2… Expand
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Highly Cited
2003
Highly Cited
2003
SAP (SLAM-associated protein) is a small lymphocyte-specific signalling molecule that is defective or absent in patients with X… Expand
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Highly Cited
1998
Highly Cited
1998
X-linked lymphoproliferative syndrome (XLP) is an inherited immunodeficiency characterized by increased susceptibility to Epstein… Expand
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Highly Cited
1996
Highly Cited
1996
A critical step in the pre-mRNA splicing reaction is the stable binding of U2 snRNP to the branchpoint sequence (BPS) to form the… Expand
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