Skip to search formSkip to main contentSkip to account menu

SGX 523

Known as: MET Tyrosine Kinase Inhibitor SGX523, SGX-523, SGX523 
An orally bioavailable small molecule, c-Met inhibitor with potential antineoplastic activity. MET receptor tyrosine kinase inhibitor SGX523… 
National Institutes of Health

Related topics

Related topics

1 relation
Receptor Tyrosine Kinase Inhibition

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Synthesis and biological evaluation of new [1,2,4]triazolo[4,3-a]pyridine derivatives as potential c-Met inhibitors.
2015
2015
T6 MET targeted therapy in Lung adenocarcinoma: Does ‘Resistant’ EGFR make a MET-responsive dimer?
Introduction Lung cancer has extremely poor survival with few effective treatments. Activating EGFR mutations (e.g. L858R… 
2015
2015
Effects of the M 4 positive allosteric modulator VU 0467154 on cognition and electrophysiological properties in the mPFC in a rodent model of NMDA receptor hypofunction
Uropathogenic Escherichia coli (UPEC) are the primary cause of urinary tract infections. UPEC undergo a transient intracellular… 
2014
2014
Abstract 1710: Bortezomib and lenalidomide resistant myeloma cells overexpress the hepatocyte growth factor/MET signaling axis and respond to MET kinase inhibitors
Multiple Myeloma (MM) is a plasma cell neoplasm that responds well to therapeutic agents such as bortezomib, a proteasome… 
2013
2013
Strengthening Context-Dependent Anticancer Effects on Non–Small Cell Lung Carcinoma by Inhibition of Both MET and EGFR
The MET and EGFR receptor tyrosine kinases (RTK) are often coexpressed and may cross-talk in driving the development and… 
Review
2007
Review
2007
In vitro and in vivo antitumor activities of SGX523, a novel MET inhibitor
B233 MET (c-Met, HGFR) the receptor tyrosine kinase for hepatocyte growth factor (HGF), has been implicated in oncogenesis and… 
2007
2007
Selective inhibition of MET protein receptor tyrosine kinase by SGX523
C198 SGX523 has been developed as an extremely selective inhibitor of the oncology target MET (c-Met, HGFR). This low molecular… 
Review
2000
Review
2000
[HPLC analysis of nonsteroidal antirheumatic agents in biological materials. IV. Acetic acid derivatives].
The present paper surveys the published HPLC methods estimating derivatives of acetic acid in biological materials and an HPLC… 
1991
1991
Purification of human placental trophoblast interferon by two-dimensional high performance liquid chromatography.
Human placental trophoblast challenged with Sendai virus induced IFNs mainly of the beta-type (75%) and relatively low levels of… 
1986
1986
Simple preparative two-step purification of interleukin-2 from culture medium of lectin stimulated normal human lymphocytes.
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)