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Transformation of mammalian cells by constitutively active MAP kinase kinase.
Mitogen-activated protein (MAP) kinase kinase (MAPKK) activates MAP kinase in a signal transduction pathway that mediates cellular responses to growth and differentiation factors. Oncogenes such asExpand
Cytoplasmic control of nuclear behavior during meiotic maturation of frog oocytes.
The title of this article is taken from a 1971 publication by Yoshio Masui and Clement Markert in which they describe the discoveries of the meiotic regulatory activities maturation promoting factorExpand
Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor.
Anthrax lethal toxin, produced by the bacterium Bacillus anthracis, is the major cause of death in animals infected with anthrax. One component of this toxin, lethal factor (LF), is suspected to be aExpand
Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product.
Hepatocyte growth factor (HGF) is a plasminogen-like protein thought to be a humoral mediator of liver regeneration. A 145-kilodalton tyrosyl phosphoprotein observed in rapid response to HGFExpand
The 3'-untranslated regions of c-mos and cyclin mRNAs stimulate translation by regulating cytoplasmic polyadenylation.
Early in the development of many animals, before transcription begins, any change in the pattern of protein synthesis is attributable to a change in the translational activity or stability of an mRNAExpand
Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner.
Exposure of mammalian cells to ionizing radiation (IR) induces a complex array of cellular responses including cell cycle arrest and/or apoptosis. IR-induced G1 arrest has been shown to depend on theExpand
Novel Therapeutic Inhibitors of the c-Met Signaling Pathway in Cancer
A wide variety of human malignancies exhibit sustained c-Met stimulation, overexpression, or mutation, including carcinomas of the breast, liver, lung, ovary, kidney, and thyroid. Notably, activatingExpand
Mos stimulates MAP kinase in Xenopus oocytes and activates a MAP kinase kinase in vitro.
Several protein kinases, including Mos, maturation-promoting factor (MPF), mitogen-activated protein (MAP) kinase, and MAP kinase kinase (MAPKK), are activated when Xenopus oocytes enter meiosis. DeExpand
Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways.
Hepatocyte growth factor (HGF) is a ligand of the receptor tyrosine kinase encoded by the c-Met protooncogene. HGF/Met signaling has multifunctional effects on various cell types. We sought toExpand
Met protein expression level correlates with survival in patients with late-stage nasopharyngeal carcinoma.
Met tyrosine kinase, the receptor for HGF/SF, is important in various cellular functions, including proliferation, mitogenesis, formation of branching tubules, angiogenesis, and tumor cell invasionExpand