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SERPINI1 gene

Known as: PI12, PROTEASE INHIBITOR 12, serpin family I member 1 
National Institutes of Health

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Serpinsneuroserpin

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2017
Highly Cited
2017
Tissue plasminogen activator and neuroserpin are widely expressed in the human central nervous system
Tissue plasminogen activator (tPA) is best known for its role in fibrin clot surveillance and it is widely used in thrombolytic… 
Highly Cited
2014
Highly Cited
2014
Nerve growth factor metabolic dysfunction in Down's syndrome brains.
Basal forebrain cholinergic neurons play a key role in cognition. This neuronal system is highly dependent on NGF for its… 
Highly Cited
2012
Highly Cited
2012
Identifying Context-Specific Gene Profiles of Social, Reproductive, and Mate Preference Behavior in a Fish Species with Female Mate Choice
Sensory and social inputs interact with underlying gene suites to coordinate social behavior. Here we use a naturally complex… 
Highly Cited
2009
Highly Cited
2009
Endoplasmic Reticulum-associated Degradation (ERAD) and Autophagy Cooperate to Degrade Polymerogenic Mutant Serpins*
The serpinopathies are a family of diseases characterized by the accumulation of ordered polymers of mutant protein within the… 
Highly Cited
2009
Highly Cited
2009
Plasminogen activator activity is inhibited while neuroserpin is up‐regulated in the Alzheimer disease brain
Amyloid‐beta plaques are a pathological hallmark of Alzheimer’s disease. Several proteases are known to cleave/remove amyloid… 
Highly Cited
2007
Highly Cited
2007
Neuroserpin polymorphisms and stroke risk in a biracial population: the stroke prevention in young women study
BackgroundNeuroserpin, primarily localized to CNS neurons, inhibits the adverse effects of tissue-type plasminogen activator (tPA… 
Highly Cited
2004
Highly Cited
2004
Mutants of Neuroserpin That Cause Dementia Accumulate as Polymers within the Endoplasmic Reticulum*
The dementia familial encephalopathy with neuroserpin inclusion bodies (FENIB) is caused by the accumulation of mutant… 
Highly Cited
2001
Highly Cited
2001
Neuroserpin, a Neuroprotective Factor in Focal Ischemic Stroke
Because recent studies have indicated that tissue plasminogen activator (tPA) aggravates neurodegenerative processes in many… 
Highly Cited
1999
Highly Cited
1999
Transforming growth factor‐βl as a regulator of the serpins/t‐PA axis in cerebral ischemia
The tissue type plasminogen activator (t‐PA) is a serine protease that is involved in neuronal plasticity and cell death induced… 
Highly Cited
1997
Highly Cited
1997
Expression of Neuroserpin, an Inhibitor of Tissue Plasminogen Activator, in the Developing and Adult Nervous System of the Mouse
Neuroserpin is a serine protease inhibitor of the serpin family that has been identified as an axonally secreted glycoprotein in… 
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