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Isolation of a candidate human hematopoietic stem-cell population.
We have identified a rare (0.05-0.1%) subset of human fetal bone marrow cells that contains multipotent hematopoietic precursors. The population of human precursor cells that express Thy-1 and CD34Expand
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An overview of the serpin superfamily
Serpins are a broadly distributed family of protease inhibitors that use a conformational change to inhibit target enzymes. They are central in controlling many important proteolytic cascades,Expand
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A structural model for GroEL-polypeptide recognition.
A monomeric peptide fragment of GroEL, consisting of residues 191-376, is a mini-chaperone with a functional chaperoning activity. We have solved the crystal structure at 1.7 A resolution ofExpand
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The MACPF/CDC family of pore-forming toxins
Pore‐forming toxins (PFTs) are commonly associated with bacterial pathogenesis. In eukaryotes, however, PFTs operate in the immune system or are deployed for attacking prey (e.g. venoms). This reviewExpand
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Protein-protein recognition: crystal structural analysis of a barnase-barstar complex at 2.0-A resolution.
We have solved, refined, and analyzed the 2.0-å resolution crystal structure of a 1:1 complex between the bacterial ribonuclease, barnase, and a Cys-->Ala(40,82) double mutant of its intracellularExpand
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T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I–bound peptide
Unusually long major histocompatibility complex (MHC) class I–restricted epitopes are important in immunity, but their 'bulged' conformation represents a potential obstacle to αβ T cell receptorExpand
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GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop
Gamma-aminobutyric acid (GABA) is synthesized by two isoforms of the pyridoxal 5′-phosphate–dependent enzyme glutamic acid decarboxylase (GAD65 and GAD67). GAD67 is constitutively active and isExpand
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Neutrophil apoptosis is associated with a reduction in CD16 (Fc gamma RIII) expression.
Resolution of inflammation involves removal of recruited neutrophils from inflamed sites via a noninflammatory mechanism, possibly involving neutrophil apoptosis and engulfment/phagocytosis byExpand
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The crystal structure of AF1521 a protein from Archaeoglobus fulgidus with homology to the non-histone domain of macroH2A.
MacroH2A is an unusual histone H2A variant that has an extensive C-terminal tail that comprises approximately two thirds of the protein. The C-terminal non-histone domain of macroH2A is also found inExpand
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Loss of a metal-binding site in gelsolin leads to familial amyloidosis–Finnish type
Mutations in domain 2 (D2, residues 151–266) of the actin-binding protein gelsolin cause familial amyloidosis–Finnish type (FAF). These mutations, D187N or D187Y, lead to abnormal proteolysis ofExpand
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