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SELEX Aptamer Technique

Known as: Aptamer Techniques, SELEX, Technique, SELEX Aptamer, Systematic Evolution of Ligands by Exponential Enrichment 
A method of generating a large library of randomized nucleotides and selecting NUCLEOTIDE APTAMERS by iterative rounds of in vitro selection. A… 
National Institutes of Health

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Papers overview

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Highly Cited
2014
Highly Cited
2014
A versatile activatable fluorescence probing platform for cancer cells in vitro and in vivo based on self-assembled aptamer/carbon nanotube ensembles.
Activatable aptamer probes (AAPs) have emerged as a promising strategy in cancer diagnostics, but existing AAPs remain… 
Highly Cited
2013
Highly Cited
2013
In vitro selection of modified RNA aptamers against CD44 cancer stem cell marker.
Cancer stem cells (CSCs) are a subset of tumor cells that has the ability to self-renew and to generate the diverse cells that… 
Highly Cited
2010
Highly Cited
2010
A general approach to the construction of structure-switching reporters from RNA aptamers.
Review
2006
Review
2006
Liquid chromatography, electrochromatography and capillary electrophoresis applications of DNA and RNA aptamers.
Highly Cited
2003
Highly Cited
2003
Short bioactive Spiegelmers to migraine-associated calcitonin gene-related peptide rapidly identified by a novel approach: tailored-SELEX.
We developed an integrated method to identify aptamers with only 10 fixed nucleotides through ligation and removal of primer… 
Highly Cited
2000
Highly Cited
2000
Diagnostic potential of PhotoSELEX-evolved ssDNA aptamers.
Highly Cited
1998
Highly Cited
1998
Cutting edge: novel RNA ligands able to bind CD4 antigen and inhibit CD4+ T lymphocyte function.
The value of high affinity-specific reagents in immunology is exemplified by the use of mAbs. Recent in vitro selection methods… 
Highly Cited
1997
Highly Cited
1997
In vitro selection of a 7-methyl-guanosine binding RNA that inhibits translation of capped mRNA molecules.
Using systematic evolution of ligands by exponential enrichment (SELEX), an RNA molecule was isolated that displays a 1,000-fold… 
Highly Cited
1995
Highly Cited
1995
In vitro selection of RNA ligands to substance P.
RNA ligands to the tachykinin substance P have been selected from a large pool of random sequence RNA molecules. Substance P is… 
Highly Cited
1994
Highly Cited
1994
Selection of high-affinity RNA ligands to reverse transcriptase: inhibition of cDNA synthesis and RNase H activity.
Specific, high-affinity RNA ligands to avian myeloblastosis virus and Moloney murine leukemia virus reverse transcriptases were… 
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