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SEC63 gene

Known as: SEC63, SEC63, S. CEREVISIAE, HOMOLOG OF, PRO2507 
National Institutes of Health

Papers overview

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Highly Cited
2019
Highly Cited
2019
Structure of the posttranslational Sec protein-translocation channel complex from yeast
Posttranslational translocon architecture About a third of proteins are transported into endoplasmic reticulum by the universally… 
Review
2017
Review
2017
Let’s talk about Secs: Sec61, Sec62 and Sec63 in signal transduction, oncology and personalized medicine
The heterotrimeric Sec61 complex and the dimeric Sec62/Sec63 complex are located in the membrane of the human endoplasmic… 
Highly Cited
2015
Highly Cited
2015
Cotranslational stabilization of Sec62/63 within the ER Sec61 translocon is controlled by distinct substrate-driven translocation events.
Highly Cited
2012
Highly Cited
2012
Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells
Co-translational transport of polypeptides into the endoplasmic reticulum (ER) involves the Sec61 channel and additional… 
Highly Cited
2010
Highly Cited
2010
Evolutionary Gain of Function for the ER Membrane Protein Sec62 from Yeast to Humans
We characterized interactions between the human proteins Sec62 and Sec63 as well as the putative interaction of human Sec62 with… 
2010
2010
Secondary and tertiary structure modeling reveals effects of novel mutations in polycystic liver disease genes PRKCSH and SEC63
Waanders E, Venselaar H, te Morsche RHM, de Koning DB, Kamath PS, Torres VE, Somlo S, Drenth JPH. Secondary and tertiary… 
Highly Cited
2006
Highly Cited
2006
Extensive mutational analysis of PRKCSH and SEC63 broadens the spectrum of polycystic liver disease
Autosomal dominant polycystic liver disease (PCLD) is characterized by progressive development of multiple (>20) liver cysts. Two… 
Highly Cited
2000
Highly Cited
2000
Mammalian Sec61 Is Associated with Sec62 and Sec63*
In yeast, efficient protein transport across the endoplasmic reticulum (ER) membrane may occur co-translationally or post… 
Highly Cited
1993
Highly Cited
1993
Extragenic suppressors of mutations in the cytoplasmic C terminus of SEC63 define five genes in Saccharomyces cerevisiae.
Mutations in the SEC63 gene of Saccharomyces cerevisiae affect both nuclear protein localization and translocation of proteins… 
Highly Cited
1992
Highly Cited
1992
A module of the DnaJ heat shock proteins found in malaria parasites.
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