J. Shine

Publications192
h-index56
Citations15,635
Highly Influential Citations308
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The 3'-terminal sequence of Escherichia coli 16S ribosomal RNA: complementarity to nonsense triplets and ribosome binding sites.
  • J. Shine, L. Dalgarno
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 April 1974
TLDR
It is suggested that this region of the RNA is able to interact with mRNA and that the 3'-terminal U-U-A(OH) is involved in the termination of protein synthesis through base-pairing with terminator codons. Expand
Sequence and expression of human estrogen receptor complementary DNA.
TLDR
A complementary DNA clone containing the entire translated portion of the messenger RNA for the estrogen receptor from MCF-7 human breast cancer cells was sequenced and then expressed in Chinese hamster ovary cells to give a functional protein, which suggests that steroid receptor genes and the avian erythroblastosis viral oncogene are derived from a common primordial gene. Expand
Determinant of cistron specificity in bacterial ribosomes
TLDR
Complementarity relationships between this sequence and a purine-rich tract in the ribosome binding site of different bacterial mRNAs suggest that the 3′-end of 16S RNA determines the intrinsic capacity of ribosomes to translate a particular cistron. Expand
Cloning and expression of full-length cDNA encoding human vitamin D receptor.
TLDR
Sequence comparisons demonstrate that the vitamin D receptor belongs to the steroid-receptor gene family and is closest in size and sequence to another member of this family, the thyroid hormone receptor. Expand
Rapid screening for symbiotic mutants of Rhizobium and white clover
TLDR
Symbiotic mutants of R. trifolii and white clover plant variants were isolated using Rhizobium inoculated seedlings incubated vertically on sealed petri dishes for the rapid screening of large numbers of bacteria and plants for their symbiotic capacity. Expand
Relaxin gene expression in human ovaries and the predicted structure of a human preprorelaxin by analysis of cDNA clones.
TLDR
Evidence is presented that the human genome possesses an additional relaxin‐related gene (designated human relaxin gene H2) which appears to be selectively expressed in the ovary during pregnancy and which encodes an authentic human Relaxin. Expand
ApaI dimorphism at the human vitamin D receptor gene locus.
Protein-coupled Receptors
TLDR
‘Seven transmembrane’ receptors are the site of action of the majority of clinically useful drugs, and there is also growing evidence that spontaneous mutations of the genes encoding such receptors may lead to a number of pathological conditions. Expand
Rat insulin genes: construction of plasmids containing the coding sequences.
Recombinant bacterial plasmids have been constructed that contain complementary DNA prepared from rat islets of Langerhans messenger RNA. Three plasmids contain cloned sequences representing the… Expand
Critical role for GALR1 galanin receptor in galanin regulation of neuroendocrine function and seizure activity.
TLDR
The phenotype of these mice identifies a critical role for GALR1 in neuroendocrine regulation and in mediating the anti-seizure activity of galanin. Expand
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