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Shape, size, and distribution of Ca(2+) release units and couplons in skeletal and cardiac muscles.
Excitation contraction (e-c) coupling in skeletal and cardiac muscles involves an interaction between specialized junctional domains of the sarcoplasmic reticulum (SR) and of exterior membranesExpand
Structural evidence for direct interaction between the molecular components of the transverse tubule/sarcoplasmic reticulum junction in skeletal muscle
The architecture of the junctional sarcoplasmic reticulum (SR) and transverse tubule (T tubule) membranes and the morphology of the two major proteins isolated from these membranes, the ryanodineExpand
Ryanodine receptors of striated muscles: a complex channel capable of multiple interactions.
The ryanodine receptor (RyR) is a high-conductance Ca2+ channel of the sarcoplasmic reticulum in muscle and of the endoplasmic reticulum in other cells. In striated muscle fibers, RyRs areExpand
Casq2 deletion causes sarcoplasmic reticulum volume increase, premature Ca2+ release, and catecholaminergic polymorphic ventricular tachycardia.
Cardiac calsequestrin (Casq2) is thought to be the key sarcoplasmic reticulum (SR) Ca2+ storage protein essential for SR Ca2+ release in mammalian heart. Human CASQ2 mutations are associated withExpand
Structure and development of E-C coupling units in skeletal muscle.
Excitation-contraction (e-c) coupling depends on appropriate communication between the specialized, junctional domains of the sarcolemma/transverse tubules (jSUjT) and those of the sarcoplasmicExpand
Quantitation of Ca ATPase, feet and mitochondria in superfast muscle fibres from the toadfish,Opsanus tau
SummaryThe muscle band surrounding the swimbladder of the toadfish (Opsanus tau) is one of the fastest known muscles in vertebrates. Rapid, non-fused twitches are responsible for the characteristicExpand
Ca2+ blinks: rapid nanoscopic store calcium signaling.
Luminal Ca(2+) in the endoplasmic and sarcoplasmic reticulum (ER/SR) plays an important role in regulating vital biological processes, including store-operated capacitative Ca(2+) entry,Expand
Stac3 is a component of the excitation-contraction coupling machinery and mutated in Native American myopathy
Excitation-contraction coupling, the process that regulates contractions by skeletal muscles, transduces changes in membrane voltage by activating release of Ca2+ from internal stores to initiateExpand
The relative contributions of the folds and caveolae to the surface membrane of frog skeletal muscle fibres at different sarcomere lengths.
The plasmalemmal area of striated muscle fibres is greater than the apparent surface area (A = circumference x length) because of variable folds and the invaginations of the caveolae and T‐tubules.Expand
Regulation of Ca2+ signaling in transgenic mouse cardiac myocytes overexpressing calsequestrin.
To probe the physiological role of calsequestrin in excitation-contraction coupling, transgenic mice overexpressing cardiac calsequestrin were developed. Transgenic mice exhibited 10-fold higherExpand