Role of Human Sec63 in Modulating the Steady-State Levels of Multi-Spanning Membrane Proteins

@inproceedings{Mades2012RoleOH,
  title={Role of Human Sec63 in Modulating the Steady-State Levels of Multi-Spanning Membrane Proteins},
  author={Andreas Mades and Katherina Gotthardt and Karin Awe and Jens Thorsten Stieler and Tatjana D{\"o}ring and Sabine F{\"u}ser and Reinhild Prange},
  booktitle={PloS one},
  year={2012}
}
The Sec61 translocon of the endoplasmic reticulum (ER) membrane forms an aqueous pore, allowing polypeptides to be transferred across or integrated into membranes. Protein translocation into the ER can occur co- and posttranslationally. In yeast, posttranslational translocation involves the heptameric translocase complex including its Sec62p and Sec63p subunits. The mammalian ER membrane contains orthologs of yeast Sec62p and Sec63p, but their function is poorly understood. Here, we analyzed… CONTINUE READING
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Differential effects of Sec 61 alpha - , Sec 62 - and Sec 63 - depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells . J Cell Sci

  • S Lang, J Benedix, SV Fedeles, S Schorr, C Schirra
  • 2012

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