SCRIB protein, human

Known as: SCRIB1 protein, human, Scribble, hScrib protein, human 
Protein scribble homolog (1630 aa, ~175 kDa) is encoded by the human SCRIB gene. This protein is involved in cell polarization.
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
Loss of cellular polarity is a hallmark of epithelial cancers, raising the possibility that regulators of polarity have a role in… (More)
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Highly Cited
2011
Highly Cited
2011
Cancer stem cells (CSCs) are proposed to drive tumor initiation and progression. Yet, our understanding of the cellular and… (More)
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Review
2008
Review
2008
Cell polarization is crucial for the development of multicellular organisms, and aberrant cell polarization contributes to… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND Mammalian Scribble (Scrib) plays a conserved role in polarization of epithelial and neuronal cells. Polarization is… (More)
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Highly Cited
2006
Highly Cited
2006
Loss of cell polarity is one of the hallmarks of malignant carcinomas. Most of the understanding about the link between cell… (More)
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Highly Cited
2003
Highly Cited
2003
Asymmetric cell division is important in generating cell diversity from bacteria to mammals. Drosophila melanogaster neuroblasts… (More)
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Highly Cited
2003
Highly Cited
2003
Polarized cells contain numerous membrane domains, but it is unclear how the formation of these domains is coordinated to create… (More)
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Highly Cited
2000
Highly Cited
2000
The generation of membrane domains with distinct protein constituents is a hallmark of cell polarization. In epithelia… (More)
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Highly Cited
2000
Highly Cited
2000
The high-risk human papillomavirus (HPV) E6 proteins stimulate the ubiquitination and degradation of p53, dependent on the E6AP… (More)
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Highly Cited
2000
Highly Cited
2000
Loss of cell polarity and tissue architecture are characteristics of malignant cancers derived from epithelial tissues. We… (More)
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