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Sertoli-Sertoli and Sertoli-germ cell interactions and their significance in germ cell movement in the seminiferous epithelium during spermatogenesis.
This review focuses on the process by which a single spermatogonium develops into 256 spermatozoa, one of which will fertilize the ovum, and recaps recent developments in the field.
The Blood-Testis Barrier and Its Implications for Male Contraception
Multiple potential targets are present at the BTB for innovative contraceptive development and for better delivery of drugs to alleviate toxicant-induced reproductive dysfunction in men, as well as critically evaluate findings in the field regarding studies on drug transporters in the testis.
Cadmium-induced testicular injury.
Cell junction dynamics in the testis: Sertoli-germ cell interactions and male contraceptive development.
The physiology and biology of junction dynamics in the testis, in particular how these events affect interactions of Sertoli and germ cells in the seminiferous epithelium behind the blood-testis barrier are discussed.
Disruption of Mtmr2 produces CMT4B1-like neuropathy with myelin outfolding and impaired spermatogenesis
It is proposed that Schwann cell–autonomous loss of Mtmr2–Dlg1 interaction dysregulates membrane homeostasis in the paranodal region, thereby producing outfolding and recurrent loops of myelin.
The Mammalian Blood-Testis Barrier: Its Biology and Regulation.
The biology and regulation of the mammalian blood-testis barrier is reviewed and research areas that should be expanded in future studies are highlighted to create a unique microenvironment for the completion of meiosis and the subsequent development of spermatids into spermatozoa via spermiogenesis.
Claudin and occludin expression and function in the seminiferous epithelium
The characteristics of claudins and occludin; the expression, regulation and function of these integral membrane proteins in the seminiferous epithelium; and how these properties relate to the unique features of BTB are discussed.
Blood‐testis barrier dynamics are regulated by testosterone and cytokines via their differential effects on the kinetics of protein endocytosis and recycling in Sertoli cells
The transient opening of the blood‐testis barrier that facilitates germ cell movement is mediated via the differential effects of T and cytokines on the kinetics of endocytosis and recycling of integral membrane proteins at the BTB.