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SCH 717454

Known as: Immunoglobulin G1, Anti-(Human Insulin-Like Growth Factor I Receptor) (Human Monoclonal SCH 717454 Heavy Chain), Disulfide with Human Monoclonal SCH 717454 Light Chain, Dimer, Anti-IGF-1R Recombinant Monoclonal Antibody SCH 717454, SCH717454 
A recombinant, fully human monoclonal antibody directed against the insulin-like growth factor 1 receptor (IGF-1R) with potential antineoplastic… 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (1)

Monoclonal Antibodies
NCIt Antineoplastic Agent Terminologyantigen binding

Papers overview

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Highly Cited
2005
Highly Cited
2005
The CCR5 Receptor-Based Mechanism of Action of 873140, a Potent Allosteric Noncompetitive HIV Entry Inhibitor
4-{[4-({(3R)-1-Butyl-3-[(R)-cyclohexyl(hydroxy)methyl]-2,5dioxo-1,4,9-triazaspiro[5.5]undec-9-yl}methyl)phenyl]oxy}benzoic acid… 
Highly Cited
2005
Highly Cited
2005
Discovery and Characterization of Vicriviroc (SCH 417690), a CCR5 Antagonist with Potent Activity against Human Immunodeficiency Virus Type 1
ABSTRACT Inhibiting human immunodeficiency virus type 1 (HIV-1) infection by blocking the host cell coreceptors CCR5 and CXCR4 is… 
Highly Cited
2005
Highly Cited
2005
Role of CXCR2 in cigarette smoke-induced lung inflammation.
It has been hypothesized that the destruction of lung tissue observed in smokers with chronic obstructive pulmonary disease and… 
Highly Cited
2004
Highly Cited
2004
Dispersal Behavior, Boldness, and the Link to Invasiveness: A Comparison of Four Gambusia Species
Dispersal is a key element of a species' invasiveness. Although considerable work has addressed how dispersal influences the… 
Highly Cited
2004
Highly Cited
2004
Spirodiketopiperazine-Based CCR5 Inhibitor Which Preserves CC-Chemokine/CCR5 Interactions and Exerts Potent Activity against R5 Human Immunodeficiency Virus Type 1 In Vitro
ABSTRACT We identified a novel spirodiketopiperazine (SDP) derivative, AK602/ONO4128/GW873140, which specifically blocked the… 
Highly Cited
2002
Highly Cited
2002
PET study of D(1) dopamine receptor binding in neuroleptic-naive patients with schizophrenia.
OBJECTIVE Postmortem studies and a positron emission tomography (PET) study have suggested that there is a disturbance of central… 
Highly Cited
2001
Highly Cited
2001
SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection in vitro and in vivo
We describe here the identification and properties of SCH-C (SCH 351125), a small molecule inhibitor of HIV-1 entry via the CCR5… 
Highly Cited
1990
Highly Cited
1990
A comparative study on the inhibitory actions of chloramphenicol, thiamphenicol and some fluorinated derivatives.
Chloramphenicol, thiamphenicol and three fluorinated derivatives, Sch 24893, Sch 25298 and Sch 25393, were studied with respect… 
Highly Cited
1989
Highly Cited
1989
Evidence that intrarenal dopamine acts as a paracrine substance at the renal tubule.
Dopamine is synthesized within the kidney and dopamine 1 (DA1) receptors are associated with the proximal tubule. In… 
Highly Cited
1986
Highly Cited
1986
Preparation of 11C-labelled SCH 23390 for the in vivo study of dopamine D-1 receptors using positron emission tomography.
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