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SC 236

Known as: SC-236, SC236 
National Institutes of Health

Papers overview

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2019
2019
Role of spinal COX-1 and COX-2 in remifentanil-induced hyperalgesia in mice with incisional pain
Objective To evaluate the role of spinal COX-1 and COX-2 in remifentanil-induced hyperalgesia in mice with incisional pain… 
2018
2018
COX-2-derived PGE2 triggers hyperplastic renin expression and hyperreninemia in aldosterone synthase-deficient mice
Pharmacological inhibition or genetic loss of function defects of the renin angiotensin aldosterone system (RAAS) causes… 
2011
2011
Experimental Study on Biological Behavior Changes of Renal Cell Carcinoma RCC-949 Induced by Specific COX-2 Inhibitor SC236
Objective To explore the effects of a specific COX-2 inhibitor SC236 on biological behavior of renal cell carcinoma RCC-949… 
2009
2009
Induction of apoptosis of gastric cancer cells by a specific COX-2 inhibitor SC236
Objective:To investigate the mechanism of apoptosis inducing effect of specific COX-2 inhibitor SC236 in gastric cancer cell line… 
2008
2008
Inhibition of cyclooxygenase -2 and amphiregulin reduces cell proliferation in a colorectal cancer cell line
Background: The role of cyclooxygenase-2 (COX-2) overexpression in colorectal cancers has engaged interest in the role of COX-2… 
2003
2003
Molecular therapeutics: is one promiscuous drug against multiple targets better than combinations of molecule-specific drugs?
Two manuscripts from the same group in this issue illustrateimportant aspects relevant to the discovery and development of… 
2003
2003
A specific COX-2 inhibitor SC236 suppresses NF-κB activation by inhibition of p65 nuclear translocation
Objective To study the molecular mechanism of anti-inflammation and anti-tumor by specific COX-2 inhibitor. Methods Two human… 
2001
2001
Inhibition of tumour promoter-induced activator protein 1 activation and cell transformation by a specific COX-2 inhibitor, SC236
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