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Pharmacological analysis of cyclooxygenase-1 in inflammation.
TLDR
The results suggest that, in addition to the role of peripherally produced PGs, there is a critical, centrally mediated neurological component to inflammatory pain that is mediated at least in part by COX-2. Expand
Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents
Nature 384, 644-648 (1996) We omitted to cite an earlier report on (human) cyclooxygenase-2 structure by C. Luong et al.1.
Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic.
TLDR
Results suggest that inhibitors of COX-2 are potent antiinflammatory agents which do not produce the typical side effects associated with the nonselective,COX-1-directed antiinflammatory drugs. Expand
Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain.
TLDR
In an animal model of acute inflammation, a selective inhibitor of COX-2 inhibited edema at the inflammatory site and was analgesic but had no effect on PG production in the stomach and did not cause gastric toxicity. Expand
Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide
TLDR
1i (4-[5-(4-methylphenyl)-3-(trifluoromethyl)- H-pyrazol-1-yl]benzenesulfonamide, SC-58635, celecoxib), which is currently in phase III clinical trials for the treatment of rheumatoid arthritis and osteoarthritis, is identified. Expand
Anti-inflammatory and upper gastrointestinal effects of celecoxib in rheumatoid arthritis: a randomized controlled trial.
TLDR
All dosages of celecoxib were efficacious in the treatment of rheumatoid arthritis and did not affect COX-1 activity in the GI tract mucosa as evidenced by less frequent incidence of endoscopic ulcers compared with naproxen. Expand
COX-2, a synaptically induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex.
Postnatal development and adult function of the central nervous system are dependent on the capacity of neurons to effect long-term changes of specific properties in response to neural activity. ThisExpand
Cyclooxygenase-2 inhibition prevents delayed death of CA1 hippocampal neurons following global ischemia.
TLDR
Results suggest that COX2 activity contributes to CA1 neuronal death after global ischemia, and hippocampal prostaglandin E2 concentrations 24 h after global waschemia were decreased in drug-treated animals compared with vehicle-treated controls. Expand
Celecoxib versus diclofenac in long-term management of rheumatoid arthritis: randomised double-blind comparison
TLDR
Celecoxib showed sustained anti-inflammatory and analgesic activity similar to diclofenac, with a lower frequency of upper gastrointestinal ulceration or gastrointestinal adverse events, and tolerability was better. Expand
Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents
TLDR
The structures of unliganded murine COX-2 and complexes with flurbiprofen, indomethacin and SC-558, a selective COx-2 inhibitor, determined are explained and some of the conformational changes associated with time-dependent inhibition are demonstrated. Expand
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