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Endothelium-dependent hyperpolarization: a role in the control of vascular tone.
Endothelial-dependent relaxation of vascular smooth muscle cells evoked by a number of agonists, including cholinomimetics and substance P, is often accompanied by an increase (repolarization and/or… Expand
Role of the epithelium and acetylcholine in mediating the contraction to 5‐hydroxytryptamine in the mouse isolated trachea
The 5‐HT receptor subtype that mediates bronchocontraction and the involvement of neuronal and non‐neuronal acetylcholine was assessed in murine isolated tracheae. Atropine (1–10 nM) caused a… Expand
Endothelium-dependent relaxation of coronary arteries by noradrenaline and serotonin
Arteries relax to the vasodilators acetylcholine, substance P, ATP and bradykinin only if the endothelium is present1–4. One hypothesis is that these substances stimulate the endothelial cells to… Expand
Evidence for differential roles of nitric oxide (NO) and hyperpolarization in endothelium‐dependent relaxation of pig isolated coronary artery
1 The possible roles of endothelial and smooth muscle cell hyperpolarization and nitric oxide (NO) in endothelium‐dependent relaxation were examined in isolated rings of pig right coronary artery. 2… Expand
Adenosine mediates relaxation of human small resistance‐like coronary arteries via A2B receptors
The receptor subtype and mechanisms underlying relaxation to adenosine were examined in human isolated small coronary arteries contracted with the thromboxane A2 mimetic, 1,5,5‐hydroxy‐11α,… Expand
Apamin blocks certain neurotransmitter-induced increases in potassium permeability
Apamin1 is a neurotoxic polypeptide of known structure2,3 isolated from bee venom. Shuba and coworkers4,5 have recently shown that it abolishes the hyperpolarising action of externally-applied ATP on… Expand
Vasodilatation by acetylcholine is endothelium‐dependent: a study by sonomicrometry in canine femoral artery in vivo.
- J. Angus, G. Campbell, T. Cocks, J. Manderson
- Chemistry, Medicine
- The Journal of physiology
- 1 November 1983
External diameter of the femoral artery was measured by sonomicrometry in the anaesthetized dog. Intra‐arterial acetylcholine lowered arterial pressure and thereby passively lowered diameter. When… Expand
Lipopolysaccharide Induces Epithelium- and Prostaglandin E2-Dependent Relaxation of Mouse Isolated Trachea through Activation of Cyclooxygenase (COX)-1 and COX-2
Lipopolysaccharide (LPS), a Toll-like receptor (TLR) 4 agonist, causes airway hyperreactivity through nuclear factor-κB (NF-κB). Because NF-κB induces cyclooxygenase-2 (COX-2) to increase synthesis… Expand
Reactivity of endothelin-1 on human and canine large veins compared with large arteries in vitro.
In comparison with snake venom sarafotoxins S6, the novel, 21-amino acid peptide, endothelin may have selective coronary artery vasoconstrictor actions. We examined endothelin-1 (ET-1) in vitro in… Expand
Comparison of contractile responses to 5‐hydroxytryptamine and sumatriptan in human isolated coronary artery: synergy with the thromboxane A2‐receptor agonist, U46619
- T. Cocks, B. Kemp, D. Pruneau, J. Angus
- Medicine, Chemistry
- British journal of pharmacology
- 1 September 1993
1 The interaction between the thromboxane A2 receptor agonist, U46619 and two 5‐hydroxytryptamine (5‐HT) receptor agonists, the non‐selective, naturally occurring agonist, 5‐HT and the selective… Expand