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SB-224289

Known as: SB 224289, SB224289 
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Decreased osteoclastogenesis in serotonin-deficient mice
Peripheral serotonin, synthesized by tryptophan hydroxylase-1 (TPH1), has been shown to play a key role in several physiological… 
Highly Cited
2011
Highly Cited
2011
The serotonin transporter, gender, and 17β oestradiol in the development of pulmonary arterial hypertension.
AIMS Idiopathic and familial forms of pulmonary arterial hypertension (PAH) predominantly affect females through an unknown… 
Highly Cited
2009
Highly Cited
2009
The bovine mammary gland expresses multiple functional isoforms of serotonin receptors
Recent studies in dairy cows have demonstrated that serotonergic ligands affect milk yield and composition. Correspondingly… 
Highly Cited
2006
Highly Cited
2006
The role of serotonin (5-hydroxytryptamine1A and 1B) receptors in prostate cancer cell proliferation.
Highly Cited
2005
Highly Cited
2005
Functional Interactions between 5-Hydroxytryptamine Receptors and the Serotonin Transporter in Pulmonary Arteries
Pulmonary arterial 5-hydroxytryptamine (serotonin) (5-HT) transporter (SERT)-, 5-HT receptor expression, and 5-HT-induced… 
Highly Cited
2005
Highly Cited
2005
Interdependent Serotonin Transporter and Receptor Pathways Regulate S100A4/Mts1, a Gene Associated With Pulmonary Vascular Disease
Heightened expression of the S100 calcium–binding protein, S100A4/Mts1, is observed in pulmonary vascular disease. Loss of… 
Highly Cited
2003
Highly Cited
2003
Evidence for serotonin (5-HT)1B, 5-HT1D and 5-HT1F receptor inhibitory effects on trigeminal neurons with craniovascular input
Highly Cited
2001
Highly Cited
2001
Evidence that hypophagia induced by d-fenfluramine and d-norfenfluramine in the rat is mediated by 5-HT2C receptors
Highly Cited
1998
Highly Cited
1998
SB‐224289–a novel selective (human) 5‐HT1B receptor antagonist with negative intrinsic activity
1 Human 5‐HT1B (h5‐HT1B) and human 5‐HT1D (h5‐HT1D) receptors show remarkably similar pharmacology with few compounds… 
Highly Cited
1997
Highly Cited
1997
Stimulation of 5-HT1B receptors causes hypothermia in the guinea pig.
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