S-Methyl-5'-Thioadenosine Phosphorylase

Known as: MTAPase, MeSAdo Phosphorylase, 5'-Methylthioadenosine Phosphorylase 
S-methyl-5'-thioadenosine phosphorylase (283 aa, ~31 kDa) is encoded by the human MTAP gene. This protein plays a role in amino acid, nucleotide and… (More)
National Institutes of Health

Related topics

Related topics

9 relations
5'-Methylthioadenosine phosphorylaseAmino Acid BiosynthesisCarbohydrate MetabolismCytoplasmic matrix
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Papers overview

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Highly Cited
2016
Highly Cited
2016
MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells
The discovery of cancer dependencies has the potential to inform therapeutic strategies and to identify putative drug targets… (More)
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Highly Cited
2016
Highly Cited
2016
Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5
5-Methylthioadenosine phosphorylase (MTAP) is a key enzyme in the methionine salvage pathway. The MTAP gene is frequently deleted… (More)
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2012
2012
The MTAP-CDKN2A locus confers susceptibility to a naturally occurring canine cancer.
BACKGROUND Advantages offered by canine population substructure, combined with clinical presentations similar to human disorders… (More)
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2011
2011
Genome-wide association study identifies a new melanoma susceptibility locus at 1q21.3
We performed a genome-wide association study of melanoma in a discovery cohort of 2,168 Australian individuals with melanoma and… (More)
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Highly Cited
2010
Highly Cited
2010
ANRIL expression is associated with atherosclerosis risk at chromosome 9p21.
OBJECTIVE We tested the hypothesis that expression of transcripts adjacent to the chromosome 9p21 (Chr9p21) locus of coronary… (More)
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Highly Cited
2009
Highly Cited
2009
INK4/ARF Transcript Expression Is Associated with Chromosome 9p21 Variants Linked to Atherosclerosis
BACKGROUND Genome-wide association studies (GWAS) have linked common single nucleotide polymorphisms (SNPs) on chromosome 9p21… (More)
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Highly Cited
2009
Highly Cited
2009
Genome-wide association study identifies variants at 9p21 and 22q13 associated with development of cutaneous nevi
A high melanocytic nevi count is the strongest known risk factor for cutaneous melanoma. We conducted a genome-wide association… (More)
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Highly Cited
2003
Highly Cited
2003
Homozygous deletion of CDKN2A and codeletion of the methylthioadenosine phosphorylase gene in the majority of pleural mesotheliomas.
PURPOSE Homozygous deletions at chromosome region 9p21 targeting the CDKN2A gene have been reported as a common cytogenetic… (More)
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Highly Cited
2002
Highly Cited
2002
Methylthioadenosine phosphorylase, a gene frequently codeleted with p16(cdkN2a/ARF), acts as a tumor suppressor in a breast cancer cell line.
The human methylthioadenosine phosphorylase (MTAP) gene is located on 9p21 and is frequently homozygously deleted, along with p16… (More)
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1992
1992
Molecular analysis of deletions of the short arm of chromosome 9 in human gliomas.
Previous studies have suggested that structural abnormalities involving the short arm of chromosome 9 are frequently associated… (More)
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